Concepedia

Repeated-dose Modeling

Repeated-Dose Modeling is a compartmental pharmacokinetic modeling approach that characterizes the time-dependent accumulation and elimination of a drug following multiple administrations at fixed intervals, distinguished from single-dose models by its explicit incorporation of dosing frequency, duration, and steady-state kinetics.

10

Publications

327

Citations

34

Authors

13

Institutions

Publications per year

2017–2026

1

Parents

Publications

10

Modeling Single and Repeated Dose Pharmacokinetics of PFOA in Mice

Inchio Lou, John F. Wambaugh, Christopher Lau et al. · Toxicological Sciences · 2008 · 115 citations · Full text

, , +10

In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs

Fabiola Pizzo, Emilio Benfenati · Methods in molecular biology · 2016 · 40 citations

, , +17

A repeated-dose model of percutaneous drug absorption

Kiyoshi Kubota, Fiona Dey, S.A. Matar et al. · Applied Mathematical Modelling · 2002 · 33 citations

, , +14

Applications of methods of statistical analysis to efficient repeated-dose toxicologic tests. 2. Methods for analysis of body, liver, and kidney weight data

Carrol S. Weil, Shayne C. Gad · Toxicology and Applied Pharmacology · 1980 · 23 citations

, , +10

Modeling single and repeated dose pharmacokinetics of PFOA in mice

John F. Wambaugh, Inchio Lou, Christopher Lau et al. · Reproductive Toxicology · 2009 · 23 citations

, , +10

1–5 of 10

Authors

34

  1. HA
    Hugh A. Barton

    Research Triangle Park Foundation, United States

    2 publications · 138 citations

    2

    h-index

  2. CS
    Carrol S. Weil

    Carnegie Mellon University, United States

    2 publications · 42 citations

    2

    h-index

  3. AB
    Andrew B. Lindstrom

    Research Triangle Park Foundation, United States

    2 publications · 138 citations

    2

    h-index

  4. IL
    Inchio Lou

    University of Macau, Macao SAR China

    2 publications · 138 citations

    2

    h-index

  5. MJ
    Mark J. Strynar

    Environmental Protection Agency, United States

    2 publications · 138 citations

    2

    h-index

1–5 of 34

Institutions

13

  1. Mario Negri Institute for Pharmacological Research

    Milan, Italy

    2 h-index

    10 publications

    232 citations

  2. Research Triangle Park Foundation

    Durham, United States

    2 h-index

    12 publications

    552 citations

  3. Environmental Protection Agency

    Washington, United States

    2 h-index

    8 publications

    368 citations

  4. Center for Drug Evaluation and Research

    Silver Spring, United States

    1 h-index

    4 publications

    80 citations

  5. National Center for Environmental Health

    Atlanta, United States

    1 h-index

    2 publications

    230 citations

  6. ExxonMobil (United States)

    Irving, United States

    1 h-index

    2 publications

    34 citations

  7. University of South Carolina Beaufort

    Beaufort, United States

    1 h-index

    1 publications

    17 citations

  8. W.E. Upjohn Institute for Employment Research

    Kalamazoo, United States

    1 h-index

    1 publications

    20 citations

1–8 of 13

Venues

  1. Toxicology and Applied Pharmacology

    TAAP · 2 publications · 42 citations

    2

    h-index

  2. Pharmaceutical Research

    1 publications · 20 citations

    1

    h-index

  3. Applied Mathematical Modelling

    1 publications · 33 citations

    1

    h-index

  4. International Journal of Toxicology

    IJT · 1 publications · 17 citations

    1

    h-index

  5. International Journal of Molecular Sciences

    IJMS · 1 publications · 19 citations

    1

    h-index

1–5