Concepedia

Repeat-dose Toxicity Testing

Repeat-Dose Toxicity Testing is a toxicological assessment method that evaluates the adverse effects of prolonged or repeated exposure to a substance over a specified period, distinguishing it from acute toxicity testing by focusing on cumulative and time-dependent toxic responses.

98

Publications

3.7K

Citations

739

Authors

212

Institutions

Publications per year

2017–2026

34

Variants

Repeated-dose Toxicity Testing

Parents

Publications

98

Toxicological Assessment of 2-Methyltetrahydrofuran and Cyclopentyl Methyl Ether in Support of Their Use in Pharmaceutical Chemical Process Development

Vincent Antonucci, John B. Coleman, James B. Ferry et al. · Organic Process Research & Development · 2011 · 203 citations

, , +14

Preclinical safety profile of trastuzumab emtansine (T-DM1): Mechanism of action of its cytotoxic component retained with improved tolerability

Kirsten Achilles Poon, Kelly M. Flagella, Joseph C. Beyer et al. · Toxicology and Applied Pharmacology · 2013 · 194 citations · Full text

, , +17

Consensus report on the future of animal-free systemic toxicity testing

Marcel Leist · ALTEX · 2014 · 181 citations · Full text

, , +11

1 H NMR-based metabolomics study on repeat dose toxicity of fine particulate matter in rats after intratracheal instillation

Yannan Zhang, Hejing Hu, Yanfeng Shi et al. · The Science of The Total Environment · 2017 · 162 citations · Full text

, , +17

Collaborative study on fifteen compounds in the rat-liver Comet assay integrated into 2- and 4-week repeat-dose studies

Mike O’Donovan, Marlies De Boeck, Dominique Brault et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2010 · 110 citations

, , +11

1–5 of 98

Authors

739

  1. MC
    M Cronin

    Liverpool John Moores University, United Kingdom

    6 publications · 197 citations

    6

    h-index

  2. TS
    T.W. Schultz

    University of Tennessee at Knoxville, United States

    3 publications · 131 citations

    3

    h-index

  3. IS
    Imran Shah

    Environmental Protection Agency, United States

    3 publications · 110 citations

    3

    h-index

  4. MV
    Mathieu Vinken

    Vrije Universiteit Brussel, Belgium

    3 publications · 62 citations

    3

    h-index

  5. CS
    Carrol S. Weil

    Carnegie Mellon University, United States

    3 publications · 59 citations

    3

    h-index

1–5 of 739

Institutions

212

  1. Research Triangle Park Foundation

    Durham, United States

    8 h-index

    34 publications

    1K citations

  2. Environmental Protection Agency

    Washington, United States

    7 h-index

    32 publications

    1K citations

  3. Pfizer (United States)

    New York, United States

    6 h-index

    36 publications

    897 citations

  4. Liverpool John Moores University

    Liverpool, United Kingdom

    6 h-index

    17 publications

    464 citations

  5. Roche (Switzerland)

    Basel, Switzerland

    5 h-index

    23 publications

    564 citations

  6. Amgen (United States)

    Thousand Oaks, United States

    4 h-index

    20 publications

    566 citations

  7. Fraunhofer Institute for Toxicology and Experimental Medicine

    Hanover, Germany

    4 h-index

    15 publications

    746 citations

  8. Bristol-Myers Squibb (United States)

    New York, United States

    4 h-index

    11 publications

    467 citations

1–8 of 212

Venues

  1. Regulatory Toxicology and Pharmacology

    RTP · 10 publications · 413 citations

    10

    h-index

  2. Toxicologic Pathology

    9 publications · 252 citations

    9

    h-index

  3. International Journal of Toxicology

    IJT · 8 publications · 166 citations

    8

    h-index

  4. Toxicological Sciences

    7 publications · 178 citations

    7

    h-index

  5. Computational Toxicology

    5 publications · 142 citations

    5

    h-index

1–5