Concepedia

Repeat-dose Administration

Repeat-Dose Administration is a methodological framework in pharmacological research that involves the systematic and controlled delivery of multiple doses of a therapeutic agent over a defined period to evaluate cumulative effects, pharmacokinetic stability, and long-term safety profiles in comparison to single-dose regimens.

274

Publications

14.3K

Citations

2.1K

Authors

661

Institutions

Publications per year

2017–2026

60

Variants

Multiple-dose Administration

Parents

Publications

274

Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals.

Yan Cai, Iman A. Hakim, James A. Crowell et al. · PubMed · 2003 · 708 citations

, , +12

Intravesical nadofaragene firadenovec gene therapy for BCG-unresponsive non-muscle-invasive bladder cancer: a single-arm, open-label, repeat-dose clinical trial

Stephen A. Boorjian, Mehrdad Alemozaffar, Badrinath R. Konety et al. · The Lancet Oncology · 2020 · 442 citations · Full text

, , +13

A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer.

Andrew M. Scott, G. Wiseman, Sydney Welt et al. · PubMed · 2003 · 442 citations

, , +17

Preclinical Safety and Pharmacokinetic Profile of Ferumoxtran-10, an Ultrasmall Superparamagnetic Iron Oxide Magnetic Resonance Contrast Agent

Philippe Bourrinet, H. H. Bengele, Bruno Bonnemain et al. · Investigative Radiology · 2006 · 331 citations

, , +17

THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN

S. J. Roffey, Soren Cole, Pierre Comby et al. · Drug Metabolism and Disposition · 2003 · 327 citations

, , +13

1–5 of 274

Authors

2.1K

  1. FN
    Flora Nasri

    University Health Network, Canada

    4 publications · 159 citations

    4

    h-index

  2. HG
    Hartej Gill

    University of Toronto, Canada

    4 publications · 159 citations

    4

    h-index

  3. OL
    Orly Lipsitz

    University Health Network, Canada

    4 publications · 159 citations

    4

    h-index

  4. RS
    Roger S. McIntyre

    University of Toronto, Canada

    4 publications · 159 citations

    4

    h-index

  5. MS
    Mehala Subramaniapillai

    University of Toronto, Canada

    4 publications · 159 citations

    4

    h-index

1–5 of 2.1K

Institutions

661

  1. Research Triangle Park Foundation

    Durham, United States

    14 h-index

    59 publications

    2K citations

  2. GlaxoSmithKline (United States)

    Philadelphia, United States

    12 h-index

    46 publications

    2K citations

  3. GlaxoSmithKline (United Kingdom)

    London, United Kingdom

    10 h-index

    63 publications

    3.7K citations

  4. University of Toronto

    Toronto, Canada

    7 h-index

    34 publications

    1.4K citations

  5. Pfizer (United States)

    New York, United States

    6 h-index

    34 publications

    1.1K citations

  6. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    12 publications

    383 citations

  7. University Health Network

    Toronto, Canada

    4 h-index

    42 publications

    1.7K citations

  8. Janssen (United States)

    Hopewell, United States

    4 h-index

    9 publications

    627 citations

1–8 of 661

Venues

  1. PubMed

    Repository · 14 publications · 1.4K citations

    11

    h-index

  2. Cancer Chemotherapy and Pharmacology

    10 publications · 462 citations

    10

    h-index

  3. The Journal of Clinical Pharmacology

    9 publications · 301 citations

    9

    h-index

  4. Antimicrobial Agents and Chemotherapy

    AAC · 9 publications · 427 citations

    9

    h-index

  5. Toxicologic Pathology

    8 publications · 256 citations

    8

    h-index

1–5