Concepedia

Regulatory Network Simplification

Regulatory Network Simplification is a methodological approach in systems biology that reduces the complexity of gene regulatory networks by eliminating redundant or non-essential regulatory interactions while preserving core functional dynamics necessary for cellular viability and phenotype expression.

8

Publications

935

Citations

26

Authors

20

Institutions

Publications per year

2017–2026

1

Parents

Publications

8

The Inferelator: an algorithm for learning parsimonious regulatory networks from systems-biology data sets de novo

Richard Bonneau, David J. Reiss, Paul Shannon et al. · Genome biology · 2006 · 546 citations · Full text

, , +17

Optimizing information flow in small genetic networks

Gašper Tkačik, Aleksandra M. Walczak, William Bialek · Physical Review E · 2009 · 139 citations · Full text

, , +15

The transition from differential equations to Boolean networks: A case study in simplifying a regulatory network model

Maria Davidich, Stefan Bornholdt · Journal of Theoretical Biology · 2008 · 120 citations

, , +13

Studying alternative splicing regulatory networks through partial correlation analysis

Liang Chen, Sika Zheng · Genome biology · 2009 · 60 citations · Full text

, , +13

Finding Robust Adaptation Gene Regulatory Networks Using Multi-Objective Genetic Algorithm

Hai‐Peng Ren, Xiao-Na Huang, Jiaxuan Hao · IEEE/ACM Transactions on Computational Biology and Bioinformatics · 2015 · 24 citations

, , +12

1–5 of 8

Authors

26

  1. DV
    David Velázquez‐Fernández

    Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico

    1 publications · 17 citations

    1

    h-index

  2. MH
    Miguel Herrera-Hernández

    Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico

    1 publications · 17 citations

    1

    h-index

  3. LC
    Liang Chen

    University of Southern California, United States

    1 publications · 60 citations

    1

    h-index

  4. PS
    Paul Shannon

    Institute for Systems Biology, United States

    1 publications · 546 citations

    1

    h-index

  5. AC
    Amancio Carnero

    Instituto de Biomedicina de Sevilla, Spain

    1 publications · 14 citations

    1

    h-index

1–5 of 26

Institutions

20

  1. InSysBio (Russia)

    Moscow, Russia

    1 h-index

    6 publications

    3.3K citations

  2. Hospital Universitario Virgen del Rocío

    Seville, Spain

    1 h-index

    2 publications

    28 citations

  3. Hexi University

    Zhangye, China

    1 h-index

    1 publications

    24 citations

  4. New York University

    New York, United States

    1 h-index

    1 publications

    546 citations

  5. University of Pennsylvania

    Philadelphia, United States

    1 h-index

    1 publications

    139 citations

  6. Rockefeller University

    New York, United States

    1 h-index

    1 publications

    139 citations

  7. University of Bremen

    Bremen, Germany

    1 h-index

    2 publications

    240 citations

  8. Instituto de Salud Carlos III

    Madrid, Spain

    1 h-index

    2 publications

    28 citations

1–8 of 20

Venues

  1. Genome biology

    2 publications · 606 citations

    2

    h-index

  2. Physical Review E

    PRE · 1 publications · 139 citations

    1

    h-index

  3. 1

    h-index

  4. Oncotarget

    1 publications · 14 citations

    1

    h-index

  5. Journal of Theoretical Biology

    1 publications · 120 citations

    1

    h-index

1–5