Concepedia

Regulatory Element Optimization

Regulatory Element Optimization is a computational or experimental methodological approach within synthetic biology and genetic engineering that involves the systematic refinement of DNA sequences—such as promoters, enhancers, and repressors—to precisely control gene expression levels and dynamics in engineered biological systems.

8

Publications

355

Citations

44

Authors

23

Institutions

Publications per year

2017–2026

4

Parents

Publications

8

Metagenomic mining of regulatory elements enables programmable species-selective gene expression

Nathan I Johns, Antonio L. C. Gomes, Sung Sun Yim et al. · Nature Methods · 2018 · 117 citations · Full text

, , +16

Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation

Qiuping Zhou · Nucleic Acids Research · 2004 · 62 citations · Full text

, , +15

Mitoxantrone Analogues as Ligands for a Stem−Loop Structure of Tau Pre-mRNA

Yang Liu, Eleanor Peacey, John R. Dickson et al. · Journal of Medicinal Chemistry · 2009 · 54 citations

, , +14

Engineering the Biosynthesis of Late-Stage Vinblastine Precursors Precondylocarpine Acetate, Catharanthine, Tabersonine in <i>Nicotiana benthamiana</i>

Dagny Grzech, Benke Hong, Lorenzo Caputi et al. · ACS Synthetic Biology · 2022 · 34 citations · Full text

, , +16

Optimization of the human factor VIII complementary DNA expression plasmid for gene therapy of hemophilia A.

Charles R. Ill, Chi-Ling Yang, Scott Bidlingmaier et al. · PubMed · 1997 · 30 citations

, , +17

1–5 of 8

Authors

44

  1. CH
    Chih‐Ming Ho

    University of California, Los Angeles, United States

    1 publications · 28 citations

    1

    h-index

  2. SZ
    Suxin Zheng

    Shanghai Institute of Materia Medica, China

    1 publications · 54 citations

    1

    h-index

  3. KM
    Kousuke Mouri

    Jackson Laboratory, United States

    1 publications · 18 citations

    1

    h-index

  4. EP
    Eleanor Peacey

    King's College London, United Kingdom

    1 publications · 54 citations

    1

    h-index

  5. SK
    Susan Kales

    Jackson Laboratory, United States

    1 publications · 18 citations

    1

    h-index

1–5 of 44

Institutions

23

  1. Harvard University

    Cambridge, United States

    2 h-index

    8 publications

    396 citations

  2. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    2 publications

    145 citations

  3. Broad Institute

    Cambridge, United States

    2 h-index

    3 publications

    252 citations

  4. Response Biomedical (Canada)

    Vancouver, Canada

    1 h-index

    1 publications

    30 citations

  5. Jackson Laboratory

    Bar Harbor, United States

    1 h-index

    4 publications

    72 citations

  6. Nanjing University

    Nanjing, China

    1 h-index

    1 publications

    28 citations

  7. Stanford University

    Stanford, United States

    1 h-index

    2 publications

    24 citations

  8. Shanghai Jiao Tong University

    Shanghai, China

    1 h-index

    1 publications

    28 citations

1–8 of 23

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 30 citations

    2

    h-index

  2. ACS Synthetic Biology

    1 publications · 34 citations

    1

    h-index

  3. Nature Methods

    1 publications · 117 citations

    1

    h-index

  4. Journal of Medicinal Chemistry

    1 publications · 54 citations

    1

    h-index

  5. 1

    h-index

1–5