Concepedia

Redox-dependent Folding Pathways

Redox-Dependent Folding Pathways is a biochemical folding mechanism that directs the sequential formation and rearrangement of disulfide bonds in proteins through controlled oxidation and reduction reactions, thereby ensuring proper three-dimensional structure acquisition in response to redox environmental changes.

285

Publications

20.8K

Citations

1K

Authors

338

Institutions

Publications per year

2017–2026

27

Parents

Publications

285

Efficient folding of proteins with multiple disulfide bonds in the <i>Escherichia coli</i> cytoplasm

Paul Bessette, Fredrik Åslund, Jon Beckwith et al. · Proceedings of the National Academy of Sciences · 1999 · 634 citations · Full text

, , +17

SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm

Julie Lobstein, Chris Jeans, Melinda J. Faulkner et al. · Microbial Cell Factories · 2012 · 577 citations · Full text

, , +17

Protein Disulfide Isomerase Acts as a Redox-Dependent Chaperone to Unfold Cholera Toxin

Billy Tsai, Chiara Rodighiero, Wayne I. Lencer et al. · Cell · 2001 · 476 citations · Full text

, , +16

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer

Michelle Lyles, Hiram Gilbert · Biochemistry · 1991 · 415 citations

, , +17

A pathway for disulfide bond formation in vivo.

James C.A. Bardwell, Jie‐Oh Lee, Georg Jander et al. · Proceedings of the National Academy of Sciences · 1993 · 412 citations · Full text

, , +14

1–5 of 285

Authors

1K

  1. JC
    James C.A. Bardwell

    University of Michigan, United States

    12 publications · 1.8K citations

    12

    h-index

  2. RS
    Roberto Sitia

    Vita-Salute San Raffaele University, Italy

    9 publications · 987 citations

    9

    h-index

  3. LM
    Luis Moroder

    Max Planck Institute of Biochemistry, Germany

    7 publications · 441 citations

    7

    h-index

  4. BH
    Begoña Heras

    The University of Queensland, Australia

    6 publications · 395 citations

    6

    h-index

  5. CA
    Chris A. Kaiser

    Massachusetts Institute of Technology, United States

    6 publications · 1K citations

    6

    h-index

1–5 of 1K

Institutions

338

  1. University of Michigan

    Ann Arbor, United States

    14 h-index

    56 publications

    8.6K citations

  2. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    66 publications

    4.8K citations

  3. Harvard University

    Cambridge, United States

    9 h-index

    33 publications

    10.1K citations

  4. Vita-Salute San Raffaele University

    Milan, Italy

    9 h-index

    24 publications

    2.3K citations

  5. The University of Queensland

    Brisbane, Australia

    9 h-index

    44 publications

    2.4K citations

  6. Max Planck Institute of Biochemistry

    Martinsried, Germany

    8 h-index

    31 publications

    1.8K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    8 h-index

    24 publications

    2.5K citations

  8. Cornell University

    Ithaca, United States

    7 h-index

    24 publications

    793 citations

1–8 of 338

Venues

  1. Journal of Biological Chemistry

    JBC · 43 publications · 3.5K citations

    33

    h-index

  2. Biochemistry

    33 publications · 2K citations

    24

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 14 publications · 2.5K citations

    14

    h-index

  4. Antioxidants and Redox Signaling

    ARS · 10 publications · 753 citations

    10

    h-index

  5. Journal of Molecular Biology

    JMB · 9 publications · 269 citations

    9

    h-index

1–5