Concepedia

Ratio Compression

Ratio Compression is a systematic underestimation of the true abundance ratio between labeled peptides in isobaric tag quantification experiments, arising from co-isolation and fragmentation of multiple precursor ions, thereby reducing the observed dynamic range of quantified protein expression levels.

26

Publications

1.4K

Citations

164

Authors

58

Institutions

Publications per year

2017–2026

17

Parents

Publications

26

Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification

Mikhail M. Savitski, Toby Mathieson, Nico Zinn et al. · Journal of Proteome Research · 2013 · 293 citations · Full text

, , +17

Minimising iTRAQ ratio compression through understanding LC‐MS elution dependence and high‐resolution HILIC fractionation

Saw Yen Ow, Malinda Salim, Josselin Noirel et al. · PROTEOMICS · 2011 · 137 citations

, , +16

Extensive Peptide Fractionation and <i>y</i><sub>1</sub> Ion-Based Interference Detection Method for Enabling Accurate Quantification by Isobaric Labeling and Mass Spectrometry

Mingming Niu, Ji-Hoon Cho, Kiran Kodali et al. · Analytical Chemistry · 2017 · 125 citations

, , +16

Carbonyl-Reactive Tandem Mass Tags for the Proteome-Wide Quantification of N-Linked Glycans

Hannes Hahne, Patrick Neubert, Karsten Kuhn et al. · Analytical Chemistry · 2012 · 124 citations · Full text

, , +17

Delayed Fragmentation and Optimized Isolation Width Settings for Improvement of Protein Identification and Accuracy of Isobaric Mass Tag Quantification on Orbitrap-Type Mass Spectrometers

Mikhail M. Savitski, Gavain M.A. Sweetman, Manor Askenazi et al. · Analytical Chemistry · 2011 · 113 citations

, , +16

1–5 of 26

Authors

164

  1. YL
    Yuxin Li

    St. Jude Children's Research Hospital, United States

    2 publications · 152 citations

    2

    h-index

  2. BK
    Bernhard Küster

    Technical University of Munich, Germany

    2 publications · 417 citations

    2

    h-index

  3. SP
    Steven P. Gygi

    Harvard University, United States

    2 publications · 47 citations

    2

    h-index

  4. JC
    John C. Rogers

    Washington State University, United States

    2 publications · 152 citations

    2

    h-index

  5. JP
    Junmin Peng

    St. Jude Children's Research Hospital, United States

    2 publications · 152 citations

    2

    h-index

1–5 of 164

Institutions

58

  1. Harvard University

    Cambridge, United States

    3 h-index

    10 publications

    400 citations

  2. Center for Integrated Protein Science Munich

    Munich, Germany

    2 h-index

    2 publications

    417 citations

  3. University of British Columbia

    Vancouver, Canada

    2 h-index

    3 publications

    90 citations

  4. St. Jude Children's Research Hospital

    Memphis, United States

    2 h-index

    16 publications

    1.4K citations

  5. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    12 publications

    330 citations

  6. Thermo Fisher Scientific (United States)

    Waltham, United States

    2 h-index

    6 publications

    456 citations

  7. Technical University of Munich

    Munich, Germany

    2 h-index

    5 publications

    958 citations

  8. University of Chinese Academy of Sciences

    Beijing, China

    2 h-index

    3 publications

    93 citations

1–8 of 58

Venues

  1. Analytical Chemistry

    10 publications · 579 citations

    10

    h-index

  2. Journal of Proteome Research

    JPR · 7 publications · 469 citations

    7

    h-index

  3. PROTEOMICS

    3 publications · 191 citations

    3

    h-index

  4. Molecular & Cellular Proteomics

    MCP · 2 publications · 24 citations

    2

    h-index

  5. Biosensors

    1 publications · 21 citations

    1

    h-index

1–5