Concepedia

Rapamycin-inducible Dimerization Systems

Rapamycin-Inducible Dimerization Systems is a chemically inducible gene expression system that enables controlled protein-protein interaction through the small molecule rapamycin, which simultaneously binds two distinct proteins to induce their heterodimerization and thereby activate downstream transcriptional or signaling responses.

17

Publications

935

Citations

100

Authors

36

Institutions

Publications per year

2017–2026

8

Variants

Rapamycin-induced Dimerization Systems

Parents

Publications

17

Light Regulation of Protein Dimerization and Kinase Activity in Living Cells Using Photocaged Rapamycin and Engineered FKBP

Andrei V. Karginov, Yan Zou, David Shirvanyants et al. · Journal of the American Chemical Society · 2010 · 147 citations

, , +12

A Photocleavable Rapamycin Conjugate for Spatiotemporal Control of Small GTPase Activity

Nobuhiro Umeda, Tasuku Ueno, Christopher W. Pohlmeyer et al. · Journal of the American Chemical Society · 2010 · 142 citations · Full text

, , +11

Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

Matthew R. Pratt, Edmund C. Schwartz, Tom W. Muir · Proceedings of the National Academy of Sciences · 2007 · 92 citations · Full text

, , +15

Pharmacological Regulation of Protein Expression from Adeno-Associated Viral Vectors in the Eye

Alberto Auricchio, Victor M. Rivera, Tim Clackson et al. · Molecular Therapy · 2002 · 90 citations · Full text

, , +17

Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches

MyLinh T. Duong, Matthew R. Collinson-Pautz, Éva Morschl et al. · Molecular Therapy — Oncolytics · 2018 · 83 citations · Full text

, , +17

1–5 of 17

Authors

100

  1. AD
    Alexander Deiters

    North Carolina State University, United States

    3 publications · 193 citations

    3

    h-index

  2. TM
    Taylor M. Courtney

    University of Pittsburgh, United States

    2 publications · 46 citations

    2

    h-index

  3. SB
    Samuel B. Snider

    Massachusetts General Hospital, United States

    1 publications · 10 citations

    1

    h-index

  4. SC
    Stephen C. Blacklow

    Harvard University, United States

    1 publications · 22 citations

    1

    h-index

  5. YW
    Yeim We

    Korea University, South Korea

    1 publications · 30 citations

    1

    h-index

1–5 of 100

Institutions

36

  1. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    7 publications

    137 citations

  2. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    13 publications

    1.2K citations

  3. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    13 publications

    698 citations

  4. Max Planck Institute of Molecular Physiology

    Dortmund, Germany

    1 h-index

    5 publications

    270 citations

  5. Bellicum Pharmaceuticals (United States)

    Houston, United States

    1 h-index

    14 publications

    1.2K citations

  6. Penn Presbyterian Medical Center

    Philadelphia, United States

    1 h-index

    3 publications

    270 citations

  7. Université de Bordeaux

    Bordeaux, France

    1 h-index

    1 publications

    53 citations

  8. University of Massachusetts Chan Medical School

    Worcester, United States

    1 h-index

    2 publications

    106 citations

1–8 of 36

Venues

  1. Journal of the American Chemical Society

    JACS · 3 publications · 315 citations

    3

    h-index

  2. Biochemistry

    2 publications · 41 citations

    2

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 119 citations

    2

    h-index

  4. ACS Chemical Biology

    1 publications · 15 citations

    1

    h-index

  5. Angewandte Chemie International Edition

    1 publications · 54 citations

    1

    h-index

1–5