Concepedia

Rag2-mediated Recombination

RAG2-Mediated Recombination is a site-specific genetic recombination mechanism, within the broader class of V(D)J recombination processes, distinguished by its dependence on the RAG2 protein—forming a complex with RAG1—to recognize recombination signal sequences and catalyze the cleavage of DNA at bordering coding segments for the assembly of functional T-cell receptor gene configurations.

81

Publications

6.3K

Citations

390

Authors

152

Institutions

Publications per year

2017–2026

7

Parents

Publications

81

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Adam G. W. Matthews, Alex Kuo, Santiago Ramón‐Maiques et al. · Nature · 2007 · 463 citations · Full text

, , +13

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

Antonius Rolink, Fritz Melchers, Jan Andersson · Immunity · 1996 · 406 citations · Full text

, , +6

Similarities Between Initiation of V(D)J Recombination and Retroviral Integration

Dik C. van Gent, Kiyoshi Mizuuchi, Martin Gellert · Science · 1996 · 277 citations

, , +17

Neoteny in Lymphocytes: <i>Rag1</i> and <i>Rag2</i> Expression in Germinal Center B Cells

Shuhua Han, Biao Zheng, David G. Schatz et al. · Science · 1996 · 266 citations

, , +14

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2

Santiago Ramón‐Maiques, Alex Kuo, Dylan Carney et al. · Proceedings of the National Academy of Sciences · 2007 · 210 citations · Full text

, , +17

1–5 of 81

Authors

390

  1. DG
    David G. Schatz

    Yale University, United States

    8 publications · 808 citations

    8

    h-index

  2. MA
    Marjorie A. Oettinger

    Massachusetts General Hospital, United States

    7 publications · 1.1K citations

    7

    h-index

  3. LD
    Luigi D. Notarangelo

    National Institute of Allergy and Infectious Diseases, United States

    5 publications · 198 citations

    5

    h-index

  4. SD
    Stephen Desiderio

    Johns Hopkins University, United States

    5 publications · 696 citations

    5

    h-index

  5. DB
    David B. Roth

    Baylor College of Medicine, United States

    5 publications · 255 citations

    5

    h-index

1–5 of 390

Institutions

152

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    45 publications

    5K citations

  2. National Institutes of Health

    Bethesda, United States

    13 h-index

    39 publications

    3.8K citations

  3. Massachusetts General Hospital

    Boston, United States

    9 h-index

    31 publications

    4.4K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    34 publications

    5.2K citations

  5. Johns Hopkins University

    Baltimore, United States

    7 h-index

    19 publications

    2.6K citations

  6. Yale University

    New Haven, United States

    7 h-index

    13 publications

    827 citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    6 h-index

    17 publications

    1.3K citations

  8. Institut Pasteur

    Paris, France

    6 h-index

    24 publications

    2K citations

1–8 of 152

Venues

  1. Molecular and Cellular Biology

    MCB · 8 publications · 579 citations

    8

    h-index

  2. Journal of Biological Chemistry

    JBC · 7 publications · 434 citations

    7

    h-index

  3. Immunity

    7 publications · 1.1K citations

    7

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 458 citations

    5

    h-index

  5. Nucleic Acids Research

    5 publications · 367 citations

    5

    h-index

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