Concepedia

Rag1 Recombinase Complex

The RAG1 Recombinase Complex is a sequence-specific endonuclease complex that catalyzes DNA cleavage at recombination signal sequences during V(D)J recombination, distinguishing it from other recombinases by its exclusive role in initiating antigen receptor gene rearrangement through precise recognition of RSS elements.

36

Publications

2.6K

Citations

154

Authors

58

Institutions

Publications per year

2017–2026

1

Parents

Publications

36

Transcription from the RAG1 Locus Marks the Earliest Lymphocyte Progenitors in Bone Marrow

Hideya Igarashi, Sophia C. Gregory, Takafumi Yokota et al. · Immunity · 2002 · 448 citations · Full text

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Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination

Mark A. Landree, Jamie A. Wibbenmeyer, David B. Roth · Genes & Development · 1999 · 207 citations · Full text

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

D. R. Kim, Yan Dai, Cynthia L. Mundy et al. · Genes & Development · 1999 · 196 citations · Full text

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Crystal structure of the V(D)J recombinase RAG1–RAG2

Min-Sung Kim, M. Lapkouski, Wei Yang et al. · Nature · 2015 · 169 citations · Full text

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Identification of Two Catalytic Residues in RAG1 that Define a Single Active Site within the RAG1/RAG2 Protein Complex

Sebastian D. Fugmann, Isabelle Villey, Leon M. Ptaszek et al. · Molecular Cell · 2000 · 158 citations · Full text

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1–5 of 36

Authors

154

  1. DG
    David G. Schatz

    Yale University, United States

    8 publications · 517 citations

    8

    h-index

  2. MG
    Martin Gellert

    National Institutes of Health, United States

    3 publications · 250 citations

    3

    h-index

  3. MA
    Marjorie A. Oettinger

    Massachusetts General Hospital, United States

    3 publications · 303 citations

    3

    h-index

  4. SD
    Sebastian D. Fugmann

    Howard Hughes Medical Institute, United States

    2 publications · 214 citations

    2

    h-index

  5. LM
    Leon M. Ptaszek

    Massachusetts General Hospital, United States

    2 publications · 213 citations

    2

    h-index

1–5 of 154

Institutions

58

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    19 publications

    1.7K citations

  2. Yale University

    New Haven, United States

    8 h-index

    24 publications

    1.7K citations

  3. National Institutes of Health

    Bethesda, United States

    6 h-index

    25 publications

    2K citations

  4. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    4 h-index

    12 publications

    1.2K citations

  5. New York University

    New York, United States

    3 h-index

    5 publications

    324 citations

  6. Icahn School of Medicine at Mount Sinai

    New York, United States

    3 h-index

    3 publications

    272 citations

  7. Massachusetts General Hospital

    Boston, United States

    3 h-index

    12 publications

    1.4K citations

  8. Harvard University

    Cambridge, United States

    2 h-index

    7 publications

    413 citations

1–8 of 58

Venues

  1. The EMBO Journal

    3 publications · 95 citations

    3

    h-index

  2. Molecular and Cellular Biology

    MCB · 3 publications · 167 citations

    3

    h-index

  3. Journal of Clinical Immunology

    2 publications · 41 citations

    2

    h-index

  4. Nature Structural & Molecular Biology

    2 publications · 130 citations

    2

    h-index

  5. Immunogenetics

    2 publications · 134 citations

    2

    h-index

1–5