Concepedia

Rag-mediated Recombination

RAG-Mediated Recombination is a site-specific genetic recombination process mediated by the recombination-activating gene (RAG) complex that catalyzes the assembly of variable, diversity, and joining gene segments in antigen receptor loci, thereby generating combinatorial diversity in B and T cell receptors during lymphocyte development.

136

Publications

9.7K

Citations

722

Authors

255

Institutions

Publications per year

2017–2026

17

Parents

Publications

136

RAG Mutations in Human B Cell-Negative SCID

Klaus Schwarz, George H. Gauss, Leopold Ludwig et al. · Science · 1996 · 532 citations

, , +17

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

Guillermo E. Taccioli, Gary Rathbun, Eugene M. Oltz et al. · Science · 1993 · 456 citations

, , +17

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

Elli Papaemmanuil, Inmaculada Rapado, Yilong Li et al. · Nature Genetics · 2014 · 397 citations · Full text

, , +12

Rag mutations reveal robust alternative end joining

Barbara Corneo, Rebecca Wendland, Ludovic Deriano et al. · Nature · 2007 · 316 citations

, , +10

Similarities Between Initiation of V(D)J Recombination and Retroviral Integration

Dik C. van Gent, Kiyoshi Mizuuchi, Martin Gellert · Science · 1996 · 277 citations

, , +17

1–5 of 136

Authors

722

  1. PC
    Patrick C. Swanson

    CHI Health Creighton University Medical Center - Bergan Mercy, United States

    12 publications · 628 citations

    12

    h-index

  2. DG
    David G. Schatz

    Yale University, United States

    13 publications · 1.2K citations

    12

    h-index

  3. MR
    Michael R. Lieber

    University of Southern California, United States

    8 publications · 1K citations

    8

    h-index

  4. DB
    David B. Roth

    Baylor College of Medicine, United States

    7 publications · 482 citations

    7

    h-index

  5. MA
    Marjorie A. Oettinger

    Massachusetts General Hospital, United States

    7 publications · 916 citations

    7

    h-index

1–5 of 722

Institutions

255

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    56 publications

    6.7K citations

  2. Yale University

    New Haven, United States

    13 h-index

    43 publications

    3.2K citations

  3. National Institutes of Health

    Bethesda, United States

    13 h-index

    52 publications

    4.9K citations

  4. CHI Health Creighton University Medical Center - Bergan Mercy

    Omaha, United States

    9 h-index

    18 publications

    506 citations

  5. Massachusetts General Hospital

    Boston, United States

    9 h-index

    24 publications

    2.7K citations

  6. Johns Hopkins University

    Baltimore, United States

    8 h-index

    18 publications

    2.2K citations

  7. Harvard University

    Cambridge, United States

    7 h-index

    18 publications

    1.8K citations

  8. Washington University in St. Louis

    St Louis, United States

    7 h-index

    29 publications

    2.4K citations

1–8 of 255

Venues

  1. Molecular and Cellular Biology

    MCB · 14 publications · 681 citations

    13

    h-index

  2. The Journal of Immunology

    JI · 11 publications · 339 citations

    11

    h-index

  3. Nucleic Acids Research

    9 publications · 636 citations

    9

    h-index

  4. Journal of Biological Chemistry

    JBC · 8 publications · 330 citations

    8

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 740 citations

    8

    h-index

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