Concepedia

Rag-mediated Cleavage

RAG-Mediated Cleavage is a molecular mechanism in V(D)J recombination wherein the RAG endonuclease complex specifically recognizes recombination signal sequences and catalyzes the site-specific cleavage of DNA to initiate antigen receptor gene rearrangement.

65

Publications

6.1K

Citations

227

Authors

83

Institutions

Publications per year

2017–2026

3

Parents

Publications

65

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

J. Fraser McBlane, Dik C. van Gent, Dale A. Ramsden et al. · Cell · 1995 · 709 citations · Full text

, , +12

It Takes Two

David Cunningham, Kristian Skrede Gleditsch, Idean Salehyan · Journal of Conflict Resolution · 2009 · 670 citations

, , +17

It Takes Two

Jamil Zaki, Niall Bolger, Kevin N. Ochsner · Psychological Science · 2008 · 463 citations

, , +17

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.

Mark S. Schlissel, A Constantinescu, T. Morrow et al. · Genes & Development · 1993 · 374 citations · Full text

, , +17

Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX

Hua Tang Chen, Avinash Bhandoola, Michael J. Difilippantonio et al. · Science · 2000 · 318 citations · Full text

, , +17

1–5 of 65

Authors

227

  1. PC
    Patrick C. Swanson

    CHI Health Creighton University Medical Center - Bergan Mercy, United States

    11 publications · 573 citations

    11

    h-index

  2. DG
    David G. Schatz

    Yale University, United States

    9 publications · 755 citations

    9

    h-index

  3. SC
    Sathees C. Raghavan

    Indian Institute of Science Bangalore, India

    6 publications · 351 citations

    6

    h-index

  4. DB
    David B. Roth

    Baylor College of Medicine, United States

    6 publications · 470 citations

    6

    h-index

  5. MA
    Marjorie A. Oettinger

    Massachusetts General Hospital, United States

    6 publications · 1.1K citations

    6

    h-index

1–5 of 227

Institutions

83

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    15 h-index

    26 publications

    2K citations

  2. Yale University

    New Haven, United States

    10 h-index

    24 publications

    1.9K citations

  3. CHI Health Creighton University Medical Center - Bergan Mercy

    Omaha, United States

    8 h-index

    19 publications

    397 citations

  4. National Institutes of Health

    Bethesda, United States

    7 h-index

    30 publications

    6.3K citations

  5. Massachusetts General Hospital

    Boston, United States

    6 h-index

    16 publications

    3.1K citations

  6. Indian Institute of Science Bangalore

    Bengaluru, India

    5 h-index

    16 publications

    339 citations

  7. Harvard University

    Cambridge, United States

    4 h-index

    9 publications

    725 citations

  8. Baylor College of Medicine

    Houston, United States

    4 h-index

    8 publications

    910 citations

1–8 of 83

Venues

  1. Molecular and Cellular Biology

    MCB · 15 publications · 857 citations

    15

    h-index

  2. Journal of Biological Chemistry

    JBC · 8 publications · 241 citations

    8

    h-index

  3. Nucleic Acids Research

    6 publications · 268 citations

    6

    h-index

  4. Cell

    4 publications · 1.3K citations

    4

    h-index

  5. Genes & Development

    3 publications · 653 citations

    3

    h-index

1–5