Concepedia

Proteoform Characterization

Proteoform Characterization is a methodological framework in mass spectrometry-based proteomics that systematically identifies and distinguishes intact proteoforms by their precise molecular signatures, including amino acid sequence variations, post-translational modifications, and proteolytic processing, thereby resolving protein-level heterogeneity at the single-molecule level.

182

Publications

8.4K

Citations

956

Authors

319

Institutions

Publications per year

2017–2026

138

Parents

Publications

182

TopPIC: a software tool for top-down mass spectrometry-based proteoform identification and characterization

Qiang Kou, Likun Xun, Xiaowen Liu · Bioinformatics · 2016 · 282 citations · Full text

, , +17

The Human Proteoform Project: Defining the human proteome

Lloyd M. Smith, Jeffrey N. Agar, Julia Chamot‐Rooke et al. · Science Advances · 2021 · 242 citations · Full text

, , +16

Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes

Jared O. Kafader, Rafael D. Melani, Kenneth R. Durbin et al. · Nature Methods · 2020 · 194 citations · Full text

, , +14

Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry

John F. Kellie, Richard E. Higgs, John Ryder et al. · Scientific Reports · 2014 · 173 citations · Full text

, , +17

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

Norelle C. Wildburger, Thomas J. Esparza, Richard D. LeDuc et al. · Scientific Reports · 2017 · 166 citations · Full text

, , +17

1–5 of 182

Authors

956

  1. NL
    Neil L. Kelleher

    Northwestern University, United States

    27 publications · 1.8K citations

    22

    h-index

  2. RT
    Ryan T. Fellers

    Northwestern University, United States

    20 publications · 1.4K citations

    18

    h-index

  3. XL
    Xiaowen Liu

    Indiana University – Purdue University Indianapolis, United States

    14 publications · 1.2K citations

    14

    h-index

  4. LP
    Ljiljana Paša‐Tolić

    Pacific Northwest National Laboratory, United States

    14 publications · 934 citations

    14

    h-index

  5. PM
    Paul M. Thomas

    Northwestern University, United States

    14 publications · 934 citations

    14

    h-index

1–5 of 956

Institutions

319

  1. Northwestern University

    Evanston, United States

    23 h-index

    168 publications

    10.9K citations

  2. Pacific Northwest National Laboratory

    Richland, United States

    15 h-index

    60 publications

    3.7K citations

  3. University of Wisconsin–Madison

    Madison, United States

    15 h-index

    97 publications

    5.6K citations

  4. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    14 h-index

    34 publications

    3.2K citations

  5. Michigan State University

    East Lansing, United States

    13 h-index

    64 publications

    2.6K citations

  6. Environmental Molecular Sciences Laboratory

    Richland, United States

    12 h-index

    41 publications

    2.3K citations

  7. Indiana University School of Medicine

    Indianapolis, United States

    11 h-index

    15 publications

    1.1K citations

  8. Utrecht University

    Utrecht, The Netherlands

    10 h-index

    36 publications

    1.8K citations

1–8 of 319

Venues

  1. Analytical Chemistry

    38 publications · 2K citations

    30

    h-index

  2. Journal of Proteome Research

    JPR · 32 publications · 1.1K citations

    22

    h-index

  3. Molecular & Cellular Proteomics

    MCP · 14 publications · 962 citations

    14

    h-index

  4. Journal of the American Society for Mass Spectrometry

    JASMS · 14 publications · 576 citations

    13

    h-index

  5. PROTEOMICS

    8 publications · 222 citations

    7

    h-index

1–5