Concepedia

Protein Sequence-structure Optimization

Protein Sequence-Structure Optimization is a computational methodology in protein design modeling that identifies amino acid sequences which fold into a target three-dimensional structure by simultaneously optimizing sequence and structural compatibility according to physical, energetic, or evolutionary criteria.

50

Publications

3K

Citations

206

Authors

88

Institutions

Publications per year

2017–2026

13

Parents

Publications

50

Principles for designing ideal protein structures

Nobuyasu Koga, Rie Koga, Gaohua Liu et al. · Nature · 2012 · 593 citations · Full text

, , +12

Characterization of a Helical Protein Designed from First Principles

Lynne Regan, William F. DeGrado · Science · 1988 · 551 citations

, , +17

Optimal sequence selection in proteins of known structure by simulated evolution.

Homme W. Hellinga, F.M. Richards · Proceedings of the National Academy of Sciences · 1994 · 127 citations

, , +16

Multistate and functional protein design using RoseTTAFold sequence space diffusion

Sidney Lisanza, Jacob Merle Gershon, S. Tipps et al. · Nature Biotechnology · 2024 · 104 citations · Full text

, , +17

Protein topology and stability define the space of allowed sequences

Patrice Koehl, Michael Levitt · Proceedings of the National Academy of Sciences · 2002 · 98 citations

, , +16

1–5 of 50

Authors

206

  1. DB
    David Baker

    University of Washington, United States

    3 publications · 728 citations

    3

    h-index

  2. AA
    Annie Aniana

    National Institutes of Health, United States

    2 publications · 98 citations

    2

    h-index

  3. TB
    Taylor B. Dolberg

    Northwestern University, United States

    2 publications · 98 citations

    2

    h-index

  4. SL
    Stephen L. Mayo

    California Institute of Technology, United States

    2 publications · 109 citations

    2

    h-index

  5. NK
    Nobuyasu Koga

    University of Washington, United States

    2 publications · 618 citations

    2

    h-index

1–5 of 206

Institutions

88

  1. University of Washington

    Seattle, United States

    5 h-index

    26 publications

    2.9K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    4 h-index

    7 publications

    2.1K citations

  3. California Institute of Technology

    Pasadena, United States

    3 h-index

    6 publications

    290 citations

  4. Stanford University

    Stanford, United States

    3 h-index

    8 publications

    334 citations

  5. National Institutes of Health

    Bethesda, United States

    2 h-index

    10 publications

    490 citations

  6. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    2 h-index

    10 publications

    490 citations

  7. Birkbeck, University of London

    London, United Kingdom

    2 h-index

    4 publications

    128 citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    2 h-index

    13 publications

    726 citations

1–8 of 88

Venues

  1. Proteins Structure Function and Bioinformatics

    4 publications · 197 citations

    4

    h-index

  2. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 67 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 263 citations

    3

    h-index

  4. The Journal of Chemical Physics

    3 publications · 80 citations

    3

    h-index

  5. PLoS Computational Biology

    2 publications · 67 citations

    2

    h-index

1–5