Concepedia

Protein Methylation Engineering

Protein Methylation Engineering is a post-translational modification engineering approach that involves the rational design and targeted manipulation of enzymatic systems to achieve site-specific methylation of amino acid residues in proteins, thereby altering their functional properties with precision.

35

Publications

1.3K

Citations

170

Authors

63

Institutions

Publications per year

2017–2026

12

Parents

Publications

35

Labeling Substrates of Protein Arginine Methyltransferase with Engineered Enzymes and Matched <i>S</i>-Adenosyl-<scp>l</scp>-methionine Analogues

Rui Wang, Weihong Zheng, Haiqiang Yu et al. · Journal of the American Chemical Society · 2011 · 131 citations

, , +13

A new tool for biotechnology: AdoMet-dependent methyltransferases

Saulius Klimašauskas, Elmar G. Weinhold · Trends in biotechnology · 2007 · 118 citations

, , +11

Bioorthogonal Profiling of Protein Methylation Using Azido Derivative of <i>S</i> -Adenosyl- <scp>l</scp> -methionine

Kabirul Islam, Ian R. Bothwell, Yuling Chen et al. · Journal of the American Chemical Society · 2012 · 106 citations

, , +13

A method to site-specifically introduce methyllysine into proteins in E. coli

Hui‐wang Ai, Jae Wook Lee, Peter G. Schultz · Chemical Communications · 2010 · 92 citations

, , +15

Defining efficient enzyme–cofactor pairs for bioorthogonal profiling of protein methylation

Kabirul Islam, Yuling Chen, Hong Wu et al. · Proceedings of the National Academy of Sciences · 2013 · 80 citations · Full text

, , +13

1–5 of 35

Authors

170

  1. ML
    Minkui Luo

    Memorial Sloan Kettering Cancer Center, United States

    5 publications · 387 citations

    5

    h-index

  2. KI
    Kabirul Islam

    University of Pittsburgh, United States

    4 publications · 224 citations

    4

    h-index

  3. HD
    Haiteng Deng

    Tsinghua University, China

    4 publications · 367 citations

    4

    h-index

  4. YC
    Yuling Chen

    Tsinghua University, China

    3 publications · 236 citations

    3

    h-index

  5. GB
    Gil Blum

    Tri-Institutional PhD Program in Chemical Biology, United States

    3 publications · 150 citations

    3

    h-index

1–5 of 170

Institutions

63

  1. Tsinghua University

    Beijing, China

    4 h-index

    7 publications

    603 citations

  2. Memorial Sloan Kettering Cancer Center

    New York, United States

    4 h-index

    14 publications

    1.2K citations

  3. Tri-Institutional PhD Program in Chemical Biology

    New York, United States

    3 h-index

    8 publications

    460 citations

  4. Scripps Research Institute

    San Diego, United States

    3 h-index

    7 publications

    514 citations

  5. Johns Hopkins University

    Baltimore, United States

    2 h-index

    9 publications

    126 citations

  6. National Institutes of Health

    Bethesda, United States

    2 h-index

    9 publications

    170 citations

  7. Rockefeller University

    New York, United States

    2 h-index

    3 publications

    368 citations

  8. University of Manchester

    Manchester, United Kingdom

    2 h-index

    14 publications

    700 citations

1–8 of 63

Venues

  1. Chemical Communications

    ChemComm · 4 publications · 183 citations

    4

    h-index

  2. Journal of the American Chemical Society

    JACS · 3 publications · 255 citations

    3

    h-index

  3. Angewandte Chemie International Edition

    2 publications · 111 citations

    2

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    2 publications · 27 citations

    2

    h-index

  5. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 2 publications · 57 citations

    2

    h-index

1–5