Concepedia

Protease-dependent Invasion

Protease-Dependent Invasion is a molecular mechanism of cancer cell infiltration characterized by the extracellular matrix degradation mediated by proteolytic enzymes, primarily matrix metalloproteinases, that enables tumor cells to breach basement membranes and invade surrounding oral tissues.

232

Publications

21.3K

Citations

1.2K

Authors

367

Institutions

Publications per year

2017–2026

12

Parents

Publications

232

A matrix metalloproteinase expressed on the surface of invasive tumour cells

Hiroshi Sato, Takahisa Takino, Yasunori Okada et al. · Nature · 1994 · 2.6K citations

, , +14

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

Paolo Mignatti, E. Robbins, Daniel B. Rifkin · Cell · 1986 · 750 citations

, , +16

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

Farideh Sabeh, Ryoko Shimizu‐Hirota, Stephen J. Weiss · The Journal of Cell Biology · 2009 · 641 citations · Full text

, , +17

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

Johanna A. Joyce, Amos Baruch, Kareem A. H. Chehade et al. · Cancer Cell · 2004 · 640 citations · Full text

, , +16

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP

Farideh Sabeh, Ichiro Ota, Kenn Holmbeck et al. · The Journal of Cell Biology · 2004 · 579 citations · Full text

, , +17

1–5 of 232

Authors

1.2K

  1. MS
    Motoharu Seiki

    The University of Tokyo, Japan

    5 publications · 2.8K citations

    5

    h-index

  2. MS
    M. Sharon Stack

    Northwestern University, United States

    4 publications · 276 citations

    4

    h-index

  3. SJ
    Stephen J. Weiss

    University of Michigan, United States

    4 publications · 1.7K citations

    4

    h-index

  4. JA
    Johanna A. Joyce

    Memorial Sloan Kettering Cancer Center, United States

    4 publications · 1.4K citations

    4

    h-index

  5. MN
    Motowo Nakajima

    SBI Pharmaceuticals (Japan), Japan

    3 publications · 171 citations

    3

    h-index

1–5 of 1.2K

Institutions

367

  1. The University of Tokyo

    Tokyo, Japan

    6 h-index

    15 publications

    702 citations

  2. Kumamoto University

    Kumamoto, Japan

    6 h-index

    28 publications

    1K citations

  3. Inserm

    Paris, France

    6 h-index

    24 publications

    1.8K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    5 h-index

    14 publications

    1.3K citations

  5. Northwestern University

    Evanston, United States

    5 h-index

    14 publications

    833 citations

  6. University of L'Aquila

    L’Aquila, Italy

    5 h-index

    18 publications

    967 citations

  7. New York University

    New York, United States

    4 h-index

    15 publications

    4.9K citations

  8. National Institute of Dental and Craniofacial Research

    Bethesda, United States

    4 h-index

    13 publications

    2.1K citations

1–8 of 367

Venues

  1. PubMed

    Repository · 31 publications · 2.1K citations

    21

    h-index

  2. Cancer Research

    10 publications · 1.2K citations

    10

    h-index

  3. International Journal of Cancer

    8 publications · 635 citations

    8

    h-index

  4. Clinical & Experimental Metastasis

    7 publications · 292 citations

    7

    h-index

  5. British Journal of Cancer

    BJC · 6 publications · 306 citations

    6

    h-index

1–5