Concepedia

Proenzyme Activation

Proenzyme Activation is a biochemical process in which an inactive precursor enzyme, known as a proenzyme, undergoes a specific molecular transformation—typically through proteolytic cleavage or conformational change—that confers catalytic activity, thereby distinguishing it from other enzyme regulatory mechanisms by its reliance on the conversion of latent forms into functionally active enzymes.

164

Publications

13.4K

Citations

610

Authors

223

Institutions

Publications per year

2017–2026

4

Variants

Zymogen Activation

Parents

Publications

164

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

S M Wilhelm, Ivan E. Collier, Barry L. Marmer et al. · Journal of Biological Chemistry · 1989 · 1.1K citations · Full text

, , +9

Calpain activation in apoptosis

Margaret Squier, Anita C.K. Miller, Alvin M. Malkinson et al. · Journal of Cellular Physiology · 1994 · 433 citations

, , +13

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

Zhiping Wang, R Jüttermann, Paul D. Soloway · Journal of Biological Chemistry · 2000 · 391 citations · Full text

, , +13

The Role of the C-terminal Domain of Human Collagenase-3 (MMP-13) in the Activation of Procollagenase-3, Substrate Specificity, and Tissue Inhibitor of Metalloproteinase Interaction

Vera Knäuper, Susan Cowell, Bryan Ronain Smith et al. · Journal of Biological Chemistry · 1997 · 348 citations · Full text

, , +14

A proenzyme form of human urokinase.

Tze-Chein Wun, Liliana Ossowski, E. Reich · Journal of Biological Chemistry · 1982 · 344 citations · Full text

, , +15

1–5 of 164

Authors

610

  1. FA
    Francesc Avilés

    Universitat Autònoma de Barcelona, Spain

    6 publications · 217 citations

    6

    h-index

  2. JV
    Josep Vendrell

    Universitat Autònoma de Barcelona, Spain

    5 publications · 147 citations

    5

    h-index

  3. NR
    Neil R. Cooper

    Scripps Health, United States

    4 publications · 223 citations

    4

    h-index

  4. AE
    Anthony E. Pegg

    Penn State Milton S. Hershey Medical Center, United States

    4 publications · 206 citations

    4

    h-index

  5. GM
    Gillian Murphy

    University of East Anglia, United Kingdom

    4 publications · 795 citations

    4

    h-index

1–5 of 610

Institutions

223

  1. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    6 h-index

    22 publications

    815 citations

  2. Kyoto University

    Kyoto, Japan

    5 h-index

    10 publications

    398 citations

  3. Washington University in St. Louis

    St Louis, United States

    5 h-index

    23 publications

    8.8K citations

  4. Pennsylvania State University

    State College, United States

    3 h-index

    8 publications

    397 citations

  5. Scripps Health

    San Diego, United States

    3 h-index

    7 publications

    221 citations

  6. University of Oxford

    Oxford, United Kingdom

    3 h-index

    5 publications

    167 citations

  7. UCB Pharma (United Kingdom)

    Slough, United Kingdom

    3 h-index

    8 publications

    1.5K citations

  8. Scripps Clinic

    La Jolla, United States

    3 h-index

    7 publications

    221 citations

1–8 of 223

Venues

  1. Journal of Biological Chemistry

    JBC · 33 publications · 5.1K citations

    32

    h-index

  2. Biochemical Journal

    BJ · 13 publications · 897 citations

    12

    h-index

  3. European Journal of Biochemistry

    EJB · 11 publications · 681 citations

    11

    h-index

  4. The Journal of Immunology

    JI · 8 publications · 487 citations

    8

    h-index

  5. PubMed

    Repository · 7 publications · 384 citations

    7

    h-index

1–5