Concepedia

Pro-neurotrophin Processing

Pro-Neurotrophin Processing is a biochemical mechanism involving the proteolytic cleavage of inactive pro-neurotrophin precursors into mature, biologically active neurotrophins, thereby regulating their signaling through Trk and p75NTR receptors in neuronal development and survival.

57

Publications

5.4K

Citations

257

Authors

118

Institutions

Publications per year

2017–2026

5

Parents

Publications

57

Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides

Ueli Gubler, Peter H. Seeburg, Beth J. Hoffman et al. · Nature · 1982 · 628 citations

, , +8

Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

Seyed Javad Mowla, H. Francis Farhadi, Sangeeta Pareek et al. · Journal of Biological Chemistry · 2001 · 558 citations · Full text

, , +16

The Precursor Pro-Nerve Growth Factor Is the Predominant Form of Nerve Growth Factor in Brain and Is Increased in Alzheimer's Disease

Margaret Fahnestock, Bernadeta Michalski, Bin Xu et al. · Molecular and Cellular Neuroscience · 2001 · 487 citations

, , +12

Cellular processing of the neurotrophin precursors of NT3 and BDNF by the mammalian proprotein convertases

Nabil G. Seidah, Suzanne Benjannet, Sangeeta Pareek et al. · FEBS Letters · 1996 · 362 citations · Full text

, , +10

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Tomoya Matsumoto, Stefanie Rauskolb, Martin Polack et al. · Nature Neuroscience · 2008 · 356 citations

, , +12

1–5 of 57

Authors

257

  1. NG
    Nabil G. Seidah

    Montreal Clinical Research Institute, Canada

    6 publications · 1.3K citations

    6

    h-index

  2. SP
    Sangeeta Pareek

    McGill University, Canada

    3 publications · 1.2K citations

    3

    h-index

  3. PK
    Patrick Kitabgi

    Centre National de la Recherche Scientifique, France

    3 publications · 138 citations

    3

    h-index

  4. PV
    Pierre Villeneuve

    McGill University, Canada

    3 publications · 98 citations

    3

    h-index

  5. RA
    Richard A. Murphy

    University of Virginia, United States

    3 publications · 1.2K citations

    3

    h-index

1–5 of 257

Institutions

118

  1. Montreal Clinical Research Institute

    Montreal, Canada

    7 h-index

    17 publications

    1.9K citations

  2. McGill University

    Montreal, Canada

    6 h-index

    13 publications

    1.8K citations

  3. Montreal Neurological Institute and Hospital

    Montreal, Canada

    5 h-index

    13 publications

    1.8K citations

  4. Université de Montréal

    Montreal, Canada

    5 h-index

    12 publications

    1.7K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    7 publications

    348 citations

  6. Université Côte d'Azur

    Nice, France

    3 h-index

    5 publications

    248 citations

  7. Inserm

    Paris, France

    3 h-index

    12 publications

    439 citations

  8. Institut de Pharmacologie Moléculaire et Cellulaire

    Valbonne, France

    2 h-index

    4 publications

    205 citations

1–8 of 118

Venues

  1. Journal of Biological Chemistry

    JBC · 4 publications · 743 citations

    4

    h-index

  2. Journal of Neurochemistry

    JNC · 4 publications · 177 citations

    4

    h-index

  3. Brain Research

    4 publications · 142 citations

    4

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 213 citations

    3

    h-index

  5. Journal of Neuroscience

    3 publications · 227 citations

    3

    h-index

1–5