Concepedia

Pro-moiety Cleavage

Pro-Moiety Cleavage is a prodrug activation mechanism in which the inert pro-moiety is selectively removed through enzymatic or chemical transformation, thereby releasing the pharmacologically active parent drug.

14

Publications

699

Citations

72

Authors

32

Institutions

Publications per year

2017–2026

4

Parents

Publications

14

Maturation of the trans-Golgi network protease furin: compartmentalization of propeptide removal, substrate cleavage, and COOH-terminal truncation.

Martin Vey, Wolfram Schäfer, Susanne Berghöfer et al. · The Journal of Cell Biology · 1994 · 155 citations · Full text

, , +16

Crystal structure of the precursor of galactose oxidase: An unusual self-processing enzyme

S.J. Firbank, Melanie S. Rogers, Carrie M. Wilmot et al. · Proceedings of the National Academy of Sciences · 2001 · 124 citations · Full text

, , +17

The Toxoplasma gondii protein MIC3 requires pro‐peptide cleavage and dimerization to function as adhesin

Odile Cérède · The EMBO Journal · 2002 · 78 citations · Full text

, , +10

Proprotein convertase furin regulates osteocalcin and bone endocrine function

Omar Al Rifai, Jacqueline Chow, Julie Lacombe et al. · Journal of Clinical Investigation · 2017 · 75 citations · Full text

, , +17

Analysis of Factor D Isoforms in Malpuech–Michels–Mingarelli–Carnevale Patients Highlights the Role of MASP-3 as a Maturase in the Alternative Pathway of Complement

Rasmus Pihl, Lisbeth Jensen, Annette G. Hansen et al. · The Journal of Immunology · 2017 · 55 citations

, , +14

1–5 of 14

Authors

72

  1. GD
    Guocheng Du

    Jiangnan University, China

    2 publications · 41 citations

    2

    h-index

  2. PH
    Patrick H. Corran

    London School of Hygiene & Tropical Medicine, United Kingdom

    1 publications · 12 citations

    1

    h-index

  3. JL
    Julie Lacombe

    Université de Montréal, Canada

    1 publications · 75 citations

    1

    h-index

  4. TH
    Tsung‐Han Hsieh

    Taipei Medical University, Taiwan

    1 publications · 20 citations

    1

    h-index

  5. IB
    Ida B. Thøgersen

    Aarhus University, Denmark

    1 publications · 55 citations

    1

    h-index

1–5 of 72

Institutions

32

  1. Jiangnan University

    Wuxi, China

    2 h-index

    12 publications

    231 citations

  2. Michigan State University

    East Lansing, United States

    2 h-index

    3 publications

    108 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    3 publications

    142 citations

  4. Bipar

    Maisons-Alfort, France

    1 h-index

    1 publications

    78 citations

  5. China Medical University Hospital

    Taichung, Taiwan

    1 h-index

    4 publications

    80 citations

  6. The University of Texas Medical Branch at Galveston

    Galveston, United States

    1 h-index

    2 publications

    64 citations

  7. General Services Administration

    Washington, United States

    1 h-index

    1 publications

    124 citations

  8. Humboldt-Universität zu Berlin

    Berlin, Germany

    1 h-index

    2 publications

    72 citations

1–8 of 32

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 173 citations

    2

    h-index

  2. PubMed

    Repository · 1 publications · 10 citations

    1

    h-index

  3. FEBS Journal

    1 publications · 36 citations

    1

    h-index

  4. Journal of Industrial Microbiology & Biotechnology

    JIM&B · 1 publications · 13 citations

    1

    h-index

  5. The Journal of Cell Biology

    JCB · 1 publications · 155 citations

    1

    h-index

1–5