Concepedia

Prion-like Propagation

Prion-Like Propagation is a pathogenic mechanism in neurodegenerative biophysics whereby misfolded protein aggregates catalyze the conformational conversion of their normally folded counterparts into toxic conformers, enabling cell-to-cell spread of proteinopathy along neural networks in a manner mechanistically analogous to prion diseases but typically without infectious transmission.

217

Publications

20K

Citations

1.3K

Authors

423

Institutions

Publications per year

2017–2026

120

Variants

Prion-like Spreading

Parents

Publications

217

Role of the Chaperone Protein Hsp104 in Propagation of the Yeast Prion-Like Factor [ <i>psi</i> <sup>+</sup> ]

Yury O. Chernoff, Susan Lindquist, Bun‐ichiro Ono et al. · Science · 1995 · 1K citations

, , +16

Prion-like spreading of pathological α-synuclein in brain

Masami Masuda‐Suzukake, Takashi Nonaka, Masato Hosokawa et al. · Brain · 2013 · 888 citations · Full text

, , +17

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Brandon B. Holmes, Sarah L. DeVos, Najla Kfoury et al. · Proceedings of the National Academy of Sciences · 2013 · 849 citations · Full text

, , +17

Brain-first versus body-first Parkinson’s disease: a multimodal imaging case-control study

Jacob Horsager, Katrine B. Andersen, Karoline Knudsen et al. · Brain · 2020 · 757 citations

, , +17

Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae

John R. Glover, Anthony S. Kowal, Eric C. Schirmer et al. · Cell · 1997 · 599 citations · Full text

, , +13

1–5 of 217

Authors

1.3K

  1. MH
    Masato Hasegawa

    Tokyo Metropolitan Institute of Medical Science, Japan

    13 publications · 2.2K citations

    13

    h-index

  2. RM
    Ronald Melki

    Centre National de la Recherche Scientifique, France

    11 publications · 991 citations

    11

    h-index

  3. LB
    Luc Bousset

    Centre National de la Recherche Scientifique, France

    8 publications · 884 citations

    8

    h-index

  4. NR
    Neil R. Cashman

    University of British Columbia, Canada

    8 publications · 856 citations

    8

    h-index

  5. BI
    Benoit I. Giasson

    University of Pennsylvania, United States

    8 publications · 451 citations

    8

    h-index

1–5 of 1.3K

Institutions

423

  1. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    66 publications

    5.3K citations

  2. Tokyo Metropolitan Institute of Medical Science

    Tokyo, Japan

    13 h-index

    64 publications

    11.2K citations

  3. University of Florida

    Gainesville, United States

    12 h-index

    72 publications

    3.9K citations

  4. National Institutes of Health

    Bethesda, United States

    10 h-index

    26 publications

    2K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    23 publications

    6.2K citations

  6. University of Oxford

    Oxford, United Kingdom

    10 h-index

    19 publications

    986 citations

  7. University of British Columbia

    Vancouver, Canada

    9 h-index

    29 publications

    5.3K citations

  8. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    9 h-index

    24 publications

    1.8K citations

1–8 of 423

Venues

  1. Journal of Biological Chemistry

    JBC · 15 publications · 1.3K citations

    15

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 2.7K citations

    15

    h-index

  3. Acta Neuropathologica Communications

    15 publications · 1.5K citations

    14

    h-index

  4. Acta Neuropathologica

    9 publications · 1.4K citations

    9

    h-index

  5. Brain

    9 publications · 2.3K citations

    9

    h-index

1–5