Concepedia

Prdm9-dependent Recombination

PRDM9-Dependent Recombination is a molecular genetic mechanism of meiotic recombination initiation in which the positioning of recombination hotspots is determined by the sequence-specific binding of the PRDM9 zinc-finger protein to genomic loci, thereby catalyzing histone methylation and recruiting recombination machinery.

39

Publications

3.1K

Citations

196

Authors

88

Institutions

Publications per year

2017–2026

16

Parents

Publications

39

Stable recombination hotspots in birds

Sonal Singhal, Ellen M. Leffler, Keerthi Sannareddy et al. · Science · 2015 · 397 citations · Full text

, , +17

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans

Ingrid Berg, Rita Neumann, Kwan-Wood Gabriel Lam et al. · Nature Genetics · 2010 · 332 citations · Full text

, , +12

Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle

Cynthia Sandor, Wanbo Li, Wouter Coppieters et al. · PLoS Genetics · 2012 · 163 citations · Full text

, , +17

PRDM9 Drives Evolutionary Erosion of Hotspots in Mus musculus through Haplotype-Specific Initiation of Meiotic Recombination

Christopher L. Baker, Shimpei Kajita, Michael Walker et al. · PLoS Genetics · 2015 · 154 citations · Full text

, , +14

Nonparadoxical evolutionary stability of the recombination initiation landscape in yeast

Isabel Lam, Scott Keeney · Science · 2015 · 144 citations · Full text

, , +16

1–5 of 39

Authors

196

  1. PM
    Petko M. Petkov

    Jackson Laboratory, United States

    8 publications · 502 citations

    8

    h-index

  2. KP
    Kenneth Paigen

    Roswell Park Comprehensive Cancer Center, United States

    5 publications · 409 citations

    5

    h-index

  3. MP
    Molly Przeworski

    Columbia University, United States

    4 publications · 513 citations

    4

    h-index

  4. AJ
    Alec J. Jeffreys

    University of Leicester, United Kingdom

    3 publications · 504 citations

    3

    h-index

  5. MW
    Michael Walker

    University of British Columbia, Canada

    3 publications · 258 citations

    3

    h-index

1–5 of 196

Institutions

88

  1. Jackson Laboratory

    Bar Harbor, United States

    8 h-index

    52 publications

    3.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    20 publications

    1.8K citations

  3. Columbia University

    New York, United States

    5 h-index

    19 publications

    1.9K citations

  4. University of Oxford

    Oxford, United Kingdom

    4 h-index

    14 publications

    2.2K citations

  5. Université de Montpellier

    Montpellier, France

    4 h-index

    10 publications

    936 citations

  6. Institut de Génétique Humaine

    Montpellier, France

    3 h-index

    9 publications

    900 citations

  7. Université Claude Bernard Lyon 1

    Villeurbanne, France

    3 h-index

    8 publications

    575 citations

  8. University of Chicago

    Chicago, United States

    3 h-index

    7 publications

    1.3K citations

1–8 of 88

Venues

  1. PLoS Genetics

    7 publications · 661 citations

    7

    h-index

  2. Science

    3 publications · 590 citations

    3

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 219 citations

    3

    h-index

  4. Molecular Biology of the Cell

    MBC · 2 publications · 127 citations

    2

    h-index

  5. Chromosoma

    2 publications · 157 citations

    2

    h-index

1–5