Concepedia

Point Mutation Activation

Point Mutation Activation is a molecular mechanism of proto-oncogene activation in which a single nucleotide substitution within the coding sequence of a proto-oncogene results in constitutive activation of its encoded protein, thereby promoting uncontrolled cell proliferation and contributing to oncogenic transformation.

39

Publications

3.4K

Citations

173

Authors

63

Institutions

Publications per year

2017–2026

0

Parents

Publications

39

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

Cornelia I. Bargmann, Mien‐Chie Hung, Robert A. Weinberg · Cell · 1986 · 1K citations

, , +11

Oncogenic activation of the neu‐encoded receptor protein by point mutation and deletion.

Cornelia I. Bargmann, Robert A. Weinberg · The EMBO Journal · 1988 · 319 citations · Full text

, , +16

A point mutation in the extracellular domain of the human CSF-1 receptor (c-fms proto-oncogene product) activates its transforming potential

Martine F. Roussel, James R. Downing, Carl W. Rettenmier et al. · Cell · 1988 · 235 citations

, , +15

A novel combination of K‐ras and myc amplification accompanied by point mutational activation of K‐ras in a human lung cancer.

Yoichi Taya, K. Hosogai, S Hirohashi et al. · The EMBO Journal · 1984 · 160 citations · Full text

, , +17

Chronic pancreatitis associated with an activation peptide mutation that facilitates trypsin activation

Niels Teich, Johann Ockenga, Albrecht Hoffmeister et al. · Gastroenterology · 2000 · 154 citations · Full text

, , +13

1–5 of 39

Authors

173

  1. MH
    Mien‐Chie Hung

    The University of Texas MD Anderson Cancer Center, United States

    5 publications · 1.2K citations

    5

    h-index

  2. LJ
    Lawrence J.T. Young

    University of California, Davis, United States

    2 publications · 130 citations

    2

    h-index

  3. NT
    Nobuo Tsuchida

    Tokyo Medical and Dental University, Japan

    2 publications · 263 citations

    2

    h-index

  4. YX
    Youming Xie

    The Barbara Ann Karmanos Cancer Institute, United States

    2 publications · 83 citations

    2

    h-index

  5. HZ
    Helmut Zarbl

    Fred Hutch Cancer Center, United States

    2 publications · 130 citations

    2

    h-index

1–5 of 173

Institutions

63

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    4 h-index

    12 publications

    457 citations

  2. University of California, Davis

    Davis, United States

    2 h-index

    5 publications

    276 citations

  3. Whitehead Institute for Biomedical Research

    Cambridge, United States

    2 h-index

    5 publications

    3.7K citations

  4. University of Hong Kong

    Pok Fu Lam, Hong Kong

    2 h-index

    7 publications

    200 citations

  5. Science Applications International Corporation (United States)

    McLean, United States

    2 h-index

    2 publications

    24 citations

  6. Genesis Laboratories

    Wellington, United States

    2 h-index

    6 publications

    68 citations

  7. University of Victoria

    Victoria, Canada

    1 h-index

    3 publications

    60 citations

  8. Uniwersytecki Szpital Dziecięcy

    Krakow, Poland

    1 h-index

    3 publications

    78 citations

1–8 of 63

Venues

  1. PubMed

    Repository · 3 publications · 73 citations

    3

    h-index

  2. Cell

    2 publications · 1.3K citations

    2

    h-index

  3. Journal of Biological Chemistry

    JBC · 2 publications · 199 citations

    2

    h-index

  4. International Journal of Cancer

    2 publications · 246 citations

    2

    h-index

  5. The EMBO Journal

    2 publications · 479 citations

    2

    h-index

1–5