Concepedia

Pka Tuning

pKa Tuning is a computational and biochemical strategy within active site engineering that refers to the deliberate modulation of the acid dissociation constant (pKa) of specific residues or functional groups in an enzyme’s active site to enhance catalytic efficiency, substrate specificity, or reaction selectivity.

128

Publications

7.6K

Citations

613

Authors

227

Institutions

Publications per year

2017–2026

43

Parents

Publications

128

Influence of the Degree of Ionization on Weak Polyelectrolyte Multilayer Assembly

Jeeyoung Choi, Michael F. Rubner · Macromolecules · 2004 · 769 citations

, , +15

Glucose-Responsive Polymer Bearing a Novel Phenylborate Derivative as a Glucose-Sensing Moiety Operating at Physiological pH Conditions

Akira Matsumoto, Syuhei Ikeda, Atsushi Harada et al. · Biomacromolecules · 2003 · 348 citations

, , +17

pKa values in organic chemistry – Making maximum use of the available data

Agnes Kütt, Sigrid Selberg, Ivari Kaljurand et al. · Tetrahedron Letters · 2018 · 210 citations

, , +16

Redox-Controlled Size-Selective Fabrication of Nanostructured Transition Metal Colloids

Manfred T. Reetz, Matthias Maase · Advanced Materials · 1999 · 193 citations

, , +17

Efficient Synthesis of Sterically Stabilized pH-Responsive Microgels of Controllable Particle Diameter by Emulsion Polymerization

Damien Dupin, Syuji Fujii, Steven P. Armes et al. · Langmuir · 2006 · 180 citations

, , +13

1–5 of 128

Authors

613

  1. HK
    Hideki Kandori

    Nagoya Institute of Technology, Japan

    2 publications · 65 citations

    2

    h-index

  2. RJ
    Richard J. Debus

    University of California, Riverside, United States

    2 publications · 90 citations

    2

    h-index

  3. NK
    Nurul Kabir

    International Center for Chemical and Biological Sciences, Pakistan

    2 publications · 205 citations

    2

    h-index

  4. AK
    Anna Kozakiewicz

    Nicolaus Copernicus University, Poland

    2 publications · 31 citations

    2

    h-index

  5. DA
    David A. Russell

    University of East Anglia, United Kingdom

    2 publications · 205 citations

    2

    h-index

1–5 of 613

Institutions

227

  1. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    12 publications

    2.1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    17 publications

    837 citations

  3. Northwestern University

    Evanston, United States

    3 h-index

    12 publications

    240 citations

  4. Ghent University

    Ghent, Belgium

    3 h-index

    8 publications

    287 citations

  5. University of British Columbia

    Vancouver, Canada

    3 h-index

    12 publications

    467 citations

  6. Hunan University

    Changsha, China

    2 h-index

    6 publications

    456 citations

  7. Nagoya Institute of Technology

    Nagoya, Japan

    2 h-index

    9 publications

    287 citations

  8. University of Notre Dame

    Notre Dame, United States

    2 h-index

    5 publications

    618 citations

1–8 of 227

Venues

  1. Biochemistry

    12 publications · 592 citations

    12

    h-index

  2. Journal of the American Chemical Society

    JACS · 10 publications · 453 citations

    10

    h-index

  3. Chemical Communications

    ChemComm · 5 publications · 296 citations

    5

    h-index

  4. Chemistry - A European Journal

    5 publications · 212 citations

    5

    h-index

  5. Inorganic Chemistry

    5 publications · 220 citations

    5

    h-index

1–5