Concepedia

Pka Matching

pKa Matching is a method in pharmaceutical chemistry that selects a salt form by aligning the pKa of the intended counterion with that of the active pharmaceutical ingredient to optimize physicochemical properties such as solubility, stability, and bioavailability.

5

Publications

317

Citations

19

Authors

5

Institutions

Publications per year

2017–2026

0

Parents

Publications

5

Elucidating the Nature of Enzyme Catalysis Utilizing a New Twist on an Old Methodology:  Quantum Mechanical−Free Energy Calculations on Chemical Reactions in Enzymes and in Aqueous Solution

Peter A. Kollman, Bernd Kuhn, Oreola Donini et al. · Accounts of Chemical Research · 2000 · 124 citations

, , +17

β-adrenergic stimulation activates early afterdepolarizations transiently via kinetic mismatch of PKA targets

Yuanfang Xie, Eleonora Grandi, Jośe L. Puglisi et al. · Journal of Molecular and Cellular Cardiology · 2013 · 71 citations

, , +14

Characterization of Low-Barrier Hydrogen Bonds. 8. Substituent Effects on the Strength and Geometry of the Formic Acid−Formate Anion Model System. An ab Initio and DFT Investigation

Ganesh A. Kumar, Michael A. McAllister · Journal of the American Chemical Society · 1998 · 64 citations

, , +17

.alpha.-Fluoro Acid and .alpha.-Fluoro Amide Analogs of Acetyl-CoA as Inhibitors of Citrate Synthase: Effect of pKa Matching on Binding Affinity and Hydrogen Bond Length

Benjamin J. Schwartz, Dale G. Drueckhammer, Ken C. Usher et al. · Biochemistry · 1995 · 30 citations

, , +11

Investigations of the Alkaline and Acid Transitions of Umecyanin, a Stellacyanin from Horseradish Roots

Christopher Dennison, Anne T. Lawler · Biochemistry · 2001 · 28 citations

, , +16

1–5 of 5

Authors

19

  1. GA
    Ganesh A. Kumar

    University of North Texas, United States

    1 publications · 64 citations

    1

    h-index

  2. MP
    Mikael Peräkylä

    University of Eastern Finland, Finland

    1 publications · 124 citations

    1

    h-index

  3. JL
    Jośe L. Puglisi

    Loyola University Chicago, United States

    1 publications · 71 citations

    1

    h-index

  4. EG
    Eleonora Grandi

    University of California, Davis, United States

    1 publications · 71 citations

    1

    h-index

  5. YX
    Yuanfang Xie

    University of California, Los Angeles, United States

    1 publications · 71 citations

    1

    h-index

1–5 of 19

Institutions

5

  1. Newcastle University

    Newcastle upon Tyne, United Kingdom

    1 h-index

    2 publications

    56 citations

  2. University of North Texas

    Denton, United States

    1 h-index

    2 publications

    128 citations

  3. University of California, San Francisco

    San Francisco, United States

    1 h-index

    6 publications

    744 citations

  4. University of California, Davis

    Davis, United States

    1 h-index

    5 publications

    355 citations

  5. Stanford University

    Stanford, United States

    1 h-index

    1 publications

    30 citations

1–5 of 5

Venues

  1. Biochemistry

    2 publications · 58 citations

    2

    h-index

  2. Journal of the American Chemical Society

    JACS · 1 publications · 64 citations

    1

    h-index

  3. Journal of Molecular and Cellular Cardiology

    1 publications · 71 citations

    1

    h-index

  4. Accounts of Chemical Research

    1 publications · 124 citations

    1

    h-index

1–4