Concepedia

Physiologically Based Elimination Modeling

Physiologically Based Elimination Modeling is a computational modeling framework that belongs to the class of elimination models and is distinguished by its explicit incorporation of anatomical, physiological, and biochemical parameters to quantitatively predict the time-course and pathways of substance clearance in living organisms.

9

Publications

235

Citations

36

Authors

11

Institutions

Publications per year

2017–2026

1

Parents

Publications

9

Estimating biotransformation rate constants of organic chemicals from modeled and measured elimination rates

Alex van der Linde, A. Jan Hendriks, Dick T.H.M. Sijm · Chemosphere · 2001 · 62 citations

, , +15

The series-compartment model for hepatic elimination.

Murray R. Gray, Y.K. Tam · Drug Metabolism and Disposition · 1987 · 35 citations

, , +17

Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals

H. Shimizu, Kosuke Yoshida, Tomohisa Nakada et al. · Drug Metabolism and Disposition · 2018 · 25 citations · Full text

, , +16

Interconnected-tubes Model of Hepatic Elimination

Yuri G. Anissimov, A. J. Bracken, Michael S. Roberts · Journal of Theoretical Biology · 1997 · 25 citations

, , +14

Scaling relationships based on partition coefficients and body sizes have similarities and interactions†

S.A.L.M. Kooijman, J. Baas, D. Bontje et al. · SAR and QSAR in environmental research · 2007 · 21 citations · Full text

, , +12

1–5 of 9

Authors

36

  1. MS
    Michael S. Roberts

    The University of Queensland, Australia

    1 publications · 25 citations

    1

    h-index

  2. AO
    Akihito Ogasawara

    Mitsubishi Tanabe Pharma Corporation

    1 publications · 25 citations

    1

    h-index

  3. MB
    Mieke Broerse

    Vrije Universiteit Amsterdam, Netherlands

    1 publications · 21 citations

    1

    h-index

  4. HY
    Hiroshi Yamazaki

    Showa Pharmaceutical University, Japan

    1 publications · 25 citations

    1

    h-index

  5. SK
    S.A.L.M. Kooijman

    Vrije Universiteit Amsterdam, Netherlands

    1 publications · 21 citations

    1

    h-index

1–5 of 36

Institutions

11

  1. Austin Hospital

    Melbourne, Australia

    1 h-index

    3 publications

    60 citations

  2. C4X Discovery (United Kingdom)

    Manchester, United Kingdom

    1 h-index

    1 publications

    17 citations

  3. The University of Queensland

    Brisbane, Australia

    1 h-index

    3 publications

    75 citations

  4. University of Georgia

    Athens, United States

    1 h-index

    1 publications

    19 citations

  5. University of Missouri

    Columbia, United States

    1 h-index

    3 publications

    33 citations

  6. Princess Alexandra Hospital

    Brisbane, Australia

    1 h-index

    1 publications

    25 citations

  7. Nederlands Instituut Publieke Veiligheid

    Arnhem, The Netherlands

    1 h-index

    2 publications

    124 citations

  8. Showa Pharmaceutical University

    Tokyo, Japan

    1 h-index

    7 publications

    175 citations

1–8 of 11

Venues

  1. Drug Metabolism and Disposition

    2 publications · 60 citations

    2

    h-index

  2. Hepatology

    1 publications · 20 citations

    1

    h-index

  3. Journal of Theoretical Biology

    1 publications · 25 citations

    1

    h-index

  4. Alternatives to Laboratory Animals

    1 publications · 17 citations

    1

    h-index

  5. Toxicology and Applied Pharmacology

    TAAP · 1 publications · 19 citations

    1

    h-index

1–5