Concepedia

Physiologically Based Bayesian Modeling

Physiologically Based Bayesian Modeling is a computational modeling framework that integrates physiologically based pharmacokinetic principles with Bayesian statistical inference to estimate population-level pharmacokinetic parameters while accounting for physiological mechanistic constraints and inter-individual variability.

38

Publications

1.6K

Citations

135

Authors

85

Institutions

Publications per year

2017–2026

6

Parents

Publications

38

Pharmacodynamic Analysis of a Fluid Challenge

Hollmann D. Aya, Irina Chis Ster, Nick Fletcher et al. · Critical Care Medicine · 2015 · 146 citations

, , +11

Minimal model S<sub>G</sub>overestimation and S<sub>I</sub>underestimation: improved accuracy by a Bayesian two-compartment model

Claudio Cobelli, Andrea Caumo, Matteo Omenetto · American Journal of Physiology-Endocrinology and Metabolism · 1999 · 115 citations

, , +12

Statistical analysis of Fisher et al. PBPK model of trichloroethylene kinetics.

Frédéric Y. Bois · Environmental Health Perspectives · 2000 · 100 citations · Full text

, , +17

Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach

Weihsueh A. Chiu, Miles S. Okino, Marina V. Evans · Toxicology and Applied Pharmacology · 2009 · 91 citations

, , +16

Population toxicokinetics of benzene.

Frédéric Y. Bois, E T Jackson, Kaija Pekari et al. · Environmental Health Perspectives · 1996 · 86 citations · Full text

, , +17

1–5 of 38

Authors

135

  1. FY
    Frédéric Y. Bois

    Institut national de l'environnement industriel et des risques, France

    7 publications · 361 citations

    7

    h-index

  2. LA
    Leon Aarons

    University of Manchester, United Kingdom

    4 publications · 109 citations

    4

    h-index

  3. FJ
    Fredrik Jönsson

    KTH Royal Institute of Technology, Sweden

    3 publications · 110 citations

    3

    h-index

  4. KP
    Kaija Pekari

    Finnish Institute of Occupational Health, Finland

    3 publications · 139 citations

    3

    h-index

  5. GJ
    Gunnar Johanson

    Karolinska Institutet, Sweden

    3 publications · 110 citations

    3

    h-index

1–5 of 135

Institutions

85

  1. University of Manchester

    Manchester, United Kingdom

    4 h-index

    11 publications

    278 citations

  2. Institut national de l'environnement industriel et des risques

    Verneuil-en-Halatte, France

    4 h-index

    4 publications

    242 citations

  3. National Center for Environmental Assessment (EPA)

    Cincinnati, United States

    3 h-index

    6 publications

    377 citations

  4. RWTH Aachen University

    Aachen, Germany

    3 h-index

    3 publications

    101 citations

  5. Colorado State University

    Fort Collins, United States

    3 h-index

    4 publications

    96 citations

  6. Environmental Protection Agency

    Washington, United States

    3 h-index

    5 publications

    365 citations

  7. Public Health Institute

    Oakland, United States

    2 h-index

    7 publications

    318 citations

  8. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    4 publications

    86 citations

1–8 of 85

Venues

  1. Environmental Health Perspectives

    EHP · 4 publications · 274 citations

    4

    h-index

  2. Toxicology and Applied Pharmacology

    TAAP · 3 publications · 157 citations

    3

    h-index

  3. 3

    h-index

  4. Toxicology

    2 publications · 77 citations

    2

    h-index

  5. PLoS ONE

    2 publications · 68 citations

    2

    h-index

1–5