Concepedia

Pathway Degeneration

Pathway Degeneration is a genomic phenomenon in which a biological pathway progressively loses functional components due to accumulated mutations, gene deletions, or pseudogenization, resulting in the partial or complete loss of the pathway's original metabolic or regulatory capacity during the process of genome reduction.

16

Publications

779

Citations

60

Authors

37

Institutions

Publications per year

2017–2026

2

Parents

Publications

16

Parallel inactivation of multiple <i>GAL</i> pathway genes and ecological diversification in yeasts

Chris Todd Hittinger, Antonis Rokas, Sean B. Carroll · Proceedings of the National Academy of Sciences · 2004 · 189 citations · Full text

, , +17

Experimental Hepatic Encephalopathy: Changes in the Binding of γ-Aminobutyric Acid

Mario Baraldi, Maria Luisa Zeneroli · Science · 1982 · 127 citations

, , +17

Glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration

S Toffa, Grazyna Kunikowska, B.‐Y. Zeng et al. · Journal of Neural Transmission · 1997 · 75 citations

, , +16

Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism

Valentina Annese, María Trinidad Herrero, M. Di Pentima et al. · Brain Structure and Function · 2014 · 71 citations

, , +17

Kraepelin and degeneration theory

Paul Hoff · European Archives of Psychiatry and Clinical Neuroscience · 2008 · 50 citations

, , +4

1–5 of 16

Authors

60

  1. AG
    Ana Gómez

    Hospital Universitario Ramón y Cajal, Spain

    1 publications · 71 citations

    1

    h-index

  2. RS
    Rebecca S. Millington

    University of Oxford, United Kingdom

    1 publications · 43 citations

    1

    h-index

  3. CL
    Clarissa Lin Yasuda

    Universidade Estadual de Campinas (UNICAMP), Brazil

    1 publications · 43 citations

    1

    h-index

  4. MF
    Martin F. Lavin

    The University of Queensland, Australia

    1 publications · 26 citations

    1

    h-index

  5. MB
    Mario Baraldi

    University of Modena and Reggio Emilia, Italy

    1 publications · 127 citations

    1

    h-index

1–5 of 60

Institutions

37

  1. National Hospital for Neurology and Neurosurgery

    London, United Kingdom

    2 h-index

    2 publications

    118 citations

  2. Imperial College London

    London, United Kingdom

    2 h-index

    2 publications

    38 citations

  3. University College London

    London, United Kingdom

    2 h-index

    3 publications

    193 citations

  4. Purchase College

    Purchase, United States

    1 h-index

    1 publications

    16 citations

  5. University Medical Center Groningen

    Groningen, The Netherlands

    1 h-index

    3 publications

    48 citations

  6. Ruhr University Bochum

    Bochum, Germany

    1 h-index

    2 publications

    48 citations

  7. University of Groningen

    Groningen, The Netherlands

    1 h-index

    3 publications

    48 citations

  8. Syracuse University

    Syracuse, United States

    1 h-index

    3 publications

    48 citations

1–8 of 37

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 189 citations

    1

    h-index

  2. Journal of Evolutionary Biology

    JEB · 1 publications · 12 citations

    1

    h-index

  3. NeuroImage Clinical

    1 publications · 26 citations

    1

    h-index

  4. Journal of Theoretical Biology

    1 publications · 23 citations

    1

    h-index

  5. 1

    h-index

1–5