Concepedia

Pathway Bottleneck Identification

Pathway Bottleneck Identification is a computational analysis method within metabolic pathway analysis that identifies rate-limiting steps or reactions that constrain flux through a metabolic network by integrating stoichiometric, thermodynamic, and regulatory constraints to pinpoint critical control points.

7

Publications

459

Citations

40

Authors

14

Institutions

Publications per year

2017–2026

4

Variants

Metabolic Pathway Bottleneck Identification

Parents

Publications

7

Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli

Kevin W. George, Mitchell G. Thompson, Aram Kang et al. · Scientific Reports · 2015 · 155 citations · Full text

, , +17

Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate

Steven Edgar, Fu‐Shuang Li, Kangjian Qiao et al. · ACS Synthetic Biology · 2016 · 77 citations

, , +17

Identification of localized and distributed bottlenecks in metabolic pathways.

Michael L. Mavrovouniotis · PubMed · 1993 · 54 citations

, , +14

Systematic identification and elimination of flux bottlenecks in the aldehyde production pathway of Synechococcus elongatus PCC 7942

Yi Ern Cheah, Yao Xu, Sarah A. Sacco et al. · Metabolic Engineering · 2020 · 51 citations · Full text

, , +13

Combinatorial analysis of enzymatic bottlenecks of l-tyrosine pathway by p-coumaric acid production in Saccharomyces cerevisiae

Jiwei Mao, Quanli Liu, Xiaofei Song et al. · Biotechnology Letters · 2017 · 49 citations

, , +17

1–5 of 7

Authors

40

  1. DW
    Daniel Wibberg

    Bielefeld University, Germany

    1 publications · 37 citations

    1

    h-index

  2. BZ
    Bastian Zirpel

    TU Dortmund University, Germany

    1 publications · 37 citations

    1

    h-index

  3. KQ
    Kangjian Qiao

    Massachusetts Institute of Technology, United States

    1 publications · 77 citations

    1

    h-index

  4. PD
    Paul D. Adams

    Lawrence Berkeley National Laboratory, United States

    1 publications · 155 citations

    1

    h-index

  5. EE
    Edward E. K. Baidoo

    Lawrence Berkeley National Laboratory, United States

    1 publications · 155 citations

    1

    h-index

1–5 of 40

Institutions

14

  1. Fraunhofer Institute for Interfacial Engineering and Biotechnology

    Stuttgart, Germany

    1 h-index

    1 publications

    36 citations

  2. Vanderbilt University

    Nashville, United States

    1 h-index

    7 publications

    357 citations

  3. Lawrence Berkeley National Laboratory

    Berkeley, United States

    1 h-index

    1 publications

    155 citations

  4. TU Dortmund University

    Dortmund, Germany

    1 h-index

    5 publications

    185 citations

  5. Technical University of Munich

    Munich, Germany

    1 h-index

    3 publications

    108 citations

  6. The University of Queensland

    Brisbane, Australia

    1 h-index

    1 publications

    36 citations

  7. Bielefeld University

    Bielefeld, Germany

    1 h-index

    2 publications

    74 citations

  8. Nankai University

    Tianjin, China

    1 h-index

    6 publications

    294 citations

1–8 of 14

Venues

  1. Scientific Reports

    2 publications · 191 citations

    2

    h-index

  2. Biotechnology Letters

    1 publications · 49 citations

    1

    h-index

  3. Journal of Biotechnology

    1 publications · 37 citations

    1

    h-index

  4. ACS Synthetic Biology

    1 publications · 77 citations

    1

    h-index

  5. PubMed

    Repository · 1 publications · 54 citations

    1

    h-index

1–5