Concepedia

Parathyroid Hormone Processing

Parathyroid Hormone Processing is a biochemical mechanism within parathyroid gland physiology that specifically involves the enzymatic cleavage and post-translational modification of preproparathyroid hormone into its biologically active, secreted form, parathyroid hormone (PTH), distinguishing it from related peptide hormone maturation processes by its tissue-specific expression and calcium-regulated secretory dynamics.

188

Publications

8.4K

Citations

648

Authors

216

Institutions

Publications per year

2017–2026

4

Parents

Publications

188

Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

Thomas Günther, Zhoufeng Chen, Jaesang Kim et al. · Nature · 2000 · 409 citations

, , +14

Mutation of the signal peptide-encoding region of the preproparathyroid hormone gene in familial isolated hypoparathyroidism.

Andrew Arnold, S A Horst, Thomas J. Gardella et al. · Journal of Clinical Investigation · 1990 · 305 citations · Full text

, , +15

A mutant PTH/PTHrP type I receptor in enchondromatosis

Sevan Hopyan, Nalan Gökgöz, Raymond Poon et al. · Nature Genetics · 2002 · 260 citations

, , +10

Prostate Specific Antigen Cleaves Parathyroid Hormone-Related Protein in the PTH-like Domain: Inactivation of PTHrP-Stimulated cAMP Accumulation in Mouse Osteoblasts

Scott D. Cramer, Zuxiong Chen, Donna M. Peehl · The Journal of Urology · 1996 · 195 citations

, , +11

Proparathyroid Hormone: Identification of a Biosynthetic Precursor to Parathyroid Hormone

Byron Kemper, Joel F. Habener, John T. Potts et al. · Proceedings of the National Academy of Sciences · 1972 · 159 citations

, , +13

1–5 of 188

Authors

648

  1. JT
    John T. Potts

    Massachusetts General Hospital, United States

    19 publications · 1K citations

    18

    h-index

  2. JF
    Joel F. Habener

    Massachusetts General Hospital, United States

    10 publications · 504 citations

    10

    h-index

  3. JW
    James W. Hamilton

    United States Department of Veterans Affairs, United States

    9 publications · 339 citations

    9

    h-index

  4. DV
    David V. Cohn

    United States Department of Veterans Affairs, United States

    9 publications · 305 citations

    9

    h-index

  5. RR
    Ronal R. MacGregor

    United States Department of Veterans Affairs, United States

    8 publications · 288 citations

    8

    h-index

1–5 of 648

Institutions

216

  1. Massachusetts General Hospital

    Boston, United States

    19 h-index

    79 publications

    6.4K citations

  2. Harvard University

    Cambridge, United States

    13 h-index

    46 publications

    4.3K citations

  3. United States Department of Veterans Affairs

    Washington, United States

    11 h-index

    39 publications

    1.4K citations

  4. McGill University

    Montreal, Canada

    10 h-index

    22 publications

    963 citations

  5. Case Western Reserve University

    Cleveland, United States

    9 h-index

    22 publications

    606 citations

  6. Washington University in St. Louis

    St Louis, United States

    9 h-index

    34 publications

    2.1K citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    8 h-index

    25 publications

    1.3K citations

  8. The University of Melbourne

    Melbourne, Australia

    8 h-index

    24 publications

    915 citations

1–8 of 216

Venues

  1. Journal of Biological Chemistry

    JBC · 23 publications · 1.2K citations

    18

    h-index

  2. Endocrinology

    20 publications · 731 citations

    16

    h-index

  3. PubMed

    Repository · 9 publications · 170 citations

    9

    h-index

  4. Bone

    9 publications · 417 citations

    9

    h-index

  5. Kidney International

    8 publications · 414 citations

    8

    h-index

1–5