Concepedia

Oxygen Fixation Hypothesis

The "Oxygen Fixation Hypothesis" is a theoretical construct in radiation biology proposing that molecular oxygen stabilizes radiation-induced DNA damage by forming covalent bonds with free radical sites on DNA, thereby preventing repair and fixing the lesion permanently.

13

Publications

857

Citations

33

Authors

15

Institutions

Publications per year

2017–2026

0

Parents

Publications

13

Chemical Radioprotection and Radiosensitization of Mammalian Cells Growing<i>in Vitro</i>

J. D. Chapman, A. P. Reuvers, J. Borsa et al. · Radiation Research · 2012 · 310 citations

, , +16

A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio

David Robert Grimes, Mike Partridge · Biomedical Physics & Engineering Express · 2015 · 189 citations · Full text

, , +17

The "oxygen paradox" of dinitrogen-fixing bacteria

Kathleen Marchal, Jozef Vanderleyden · Biology and Fertility of Soils · 2000 · 74 citations

, , +14

The Oxygen Fixation Hypothesis

David F. Ewing · American Journal of Clinical Oncology · 1998 · 52 citations

, , +17

CEREBRAL STIMULATION

ARTHUR S. LOEVENHART · Journal of the American Medical Association · 1929 · 50 citations

, , +7

1–5 of 13

Authors

33

  1. CG
    C.L. Greenstock

    Atomic Energy (Canada), Canada

    2 publications · 328 citations

    2

    h-index

  2. IJ
    Ira J. Spiro

    Massachusetts General Hospital, United States

    1 publications · 33 citations

    1

    h-index

  3. NM
    Nasrin Mirsaleh‐Kohan

    University of Tennessee at Knoxville, United States

    1 publications · 13 citations

    1

    h-index

  4. PC
    Pierre Cloutier

    Université de Sherbrooke, Canada

    1 publications · 13 citations

    1

    h-index

  5. AP
    A. P. Reuvers

    Atomic Energy (Canada), Canada

    1 publications · 310 citations

    1

    h-index

1–5 of 33

Institutions

15

  1. Atomic Energy (Canada)

    Ottawa, Canada

    2 h-index

    5 publications

    1.3K citations

  2. Research Complex at Harwell

    Harwell, United Kingdom

    1 h-index

    1 publications

    43 citations

  3. Max Planck Society

    Munich, Germany

    1 h-index

    2 publications

    42 citations

  4. Max-Planck-Institut für Kohlenforschung

    Mülheim, Germany

    1 h-index

    1 publications

    21 citations

  5. Cancer Research UK

    London, United Kingdom

    1 h-index

    2 publications

    378 citations

  6. Allegheny College

    Meadville, United States

    1 h-index

    1 publications

    52 citations

  7. KU Leuven

    Leuven, Belgium

    1 h-index

    2 publications

    148 citations

  8. Université de Sherbrooke

    Sherbrooke, Canada

    1 h-index

    5 publications

    65 citations

1–8 of 15

Venues

  1. Radiation Research

    2 publications · 330 citations

    2

    h-index

  2. 1

    h-index

  3. Heterocycles

    1 publications · 12 citations

    1

    h-index

  4. Israel Journal of Chemistry

    1 publications · 18 citations

    1

    h-index

  5. Biology and Fertility of Soils

    1 publications · 74 citations

    1

    h-index

1–5