Concepedia

Orthosteric Coupling

Orthosteric Coupling is a mechanistic principle in allosteric protein engineering that denotes the direct energetic and structural interdependence between the orthosteric site and a distant functional site within a protein, where ligand binding or perturbation at the orthosteric site allosterically modulates the protein’s activity through defined conformational or dynamic pathways.

21

Publications

935

Citations

130

Authors

71

Institutions

Publications per year

2017–2026

9

Parents

Publications

21

2P2Idb: a structural database dedicated to orthosteric modulation of protein–protein interactions

Marie Jeanne Basse, S. Betzi, Raphaël Bourgeas et al. · Nucleic Acids Research · 2012 · 147 citations · Full text

, , +17

Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

Richard B. van Breemen, Ruth N. Muchiri, Timothy A. Bates et al. · Journal of Natural Products · 2022 · 142 citations · Full text

, , +17

2P2Idb v2: update of a structural database dedicated to orthosteric modulation of protein–protein interactions

Marie-Jeanne Basse, S. Betzi, Xavier Morelli et al. · Database · 2016 · 80 citations · Full text

, , +17

Allosteric effects acting over a distance of 20-25 .ANG. in the Escherichia coli tryptophan synthase bienzyme complex increase ligand affinity and cause redistribution of covalent intermediates

Karl F. Houben, Michael F. Dunn · Biochemistry · 1990 · 64 citations

, , +17

β-Arrestin-Selective G Protein-Coupled Receptor Agonists Engender Unique Biological Efficacy in Vivo

Diane Gesty‐Palmer, Ling Yuan, Bronwen Martin et al. · Molecular Endocrinology · 2013 · 60 citations · Full text

, , +17

1–5 of 21

Authors

130

  1. PR
    Philippe Roche

    Centre National de la Recherche Scientifique, France

    3 publications · 254 citations

    3

    h-index

  2. XM
    Xavier Morelli

    Centre National de la Recherche Scientifique, France

    3 publications · 254 citations

    3

    h-index

  3. VH
    Véronique Hamon

    Inserm, France

    2 publications · 174 citations

    2

    h-index

  4. SB
    S. Betzi

    Centre National de la Recherche Scientifique, France

    2 publications · 227 citations

    2

    h-index

  5. MJ
    Marie Jeanne Basse

    Aix-Marseille Université, France

    2 publications · 174 citations

    2

    h-index

1–5 of 130

Institutions

71

  1. Inserm

    Paris, France

    4 h-index

    21 publications

    1.7K citations

  2. Aix-Marseille Université

    Marseille, France

    3 h-index

    18 publications

    1.7K citations

  3. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    2 h-index

    8 publications

    429 citations

  4. Centre de Recherche en Cancérologie de Marseille

    Marseille, France

    2 h-index

    12 publications

    1.5K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    17 publications

    1.4K citations

  6. University of Bath

    Bath, United Kingdom

    2 h-index

    2 publications

    41 citations

  7. Institut Paoli-Calmettes

    Marseille, France

    2 h-index

    10 publications

    482 citations

  8. University of Oxford

    Oxford, United Kingdom

    2 h-index

    3 publications

    67 citations

1–8 of 71

Venues

  1. Journal of Lipid Research

    JLR · 1 publications · 23 citations

    1

    h-index

  2. Chemical Communications

    ChemComm · 1 publications · 24 citations

    1

    h-index

  3. Biochemical Pharmacology

    1 publications · 11 citations

    1

    h-index

  4. Molecular Pharmacology

    1 publications · 30 citations

    1

    h-index

  5. Nature Communications

    1 publications · 28 citations

    1

    h-index

1–5