Concepedia

Origin Recognition Complex

The Origin Recognition Complex is a multiprotein molecular machine that belongs to the class of DNA replication initiation factors and is distinguished by its ability to specifically bind to genomic replication origins, thereby serving as the foundational platform for the assembly of the pre-replicative complex during the process of replication licensing.

430

Publications

34.8K

Citations

1.4K

Authors

451

Institutions

Publications per year

2017–2026

59

Variants

Orc

Parents

Publications

430

ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex

Stephen P. Bell, Bruce Stillman · Nature · 1992 · 1.3K citations

, , +16

Chromatin Association of Human Origin Recognition Complex, Cdc6, and Minichromosome Maintenance Proteins during the Cell Cycle: Assembly of Prereplication Complexes in Late Mitosis

Juan Méndez, Bruce Stillman · Molecular and Cellular Biology · 2000 · 934 citations · Full text

, , +17

Yeast Origin Recognition Complex Functions in Transcription Silencing and DNA Replication

Stephen P. Bell, Ryûji Kobayashi, Bruce Stillman · Science · 1993 · 442 citations

, , +17

Isolation of <i>ORC6</i> , a Component of the Yeast Origin Recognition Complex by a One-Hybrid System

Joachim J. Li, Ira Herskowitz · Science · 1993 · 422 citations

, , +17

Genome-Wide Distribution of ORC and MCM Proteins in <i>S. cerevisiae</i> : High-Resolution Mapping of Replication Origins

John J. Wyrick, Jennifer G. Aparicio, Ting Chen et al. · Science · 2001 · 416 citations

, , +14

1–5 of 430

Authors

1.4K

  1. BS
    Bruce Stillman

    Cold Spring Harbor Laboratory, United States

    33 publications · 6.2K citations

    32

    h-index

  2. SP
    Stephen P. Bell

    Massachusetts Institute of Technology, United States

    19 publications · 4.3K citations

    18

    h-index

  3. CA
    Catherine A. Fox

    University of Wisconsin–Madison, United States

    18 publications · 1.2K citations

    17

    h-index

  4. AD
    Anindya Dutta

    University of Virginia, United States

    15 publications · 1.3K citations

    15

    h-index

  5. MR
    Michael R. Botchan

    University of California, Berkeley, United States

    13 publications · 1.5K citations

    13

    h-index

1–5 of 1.4K

Institutions

451

  1. Cold Spring Harbor Laboratory

    Cold Spring Harbor, United States

    34 h-index

    116 publications

    16.2K citations

  2. University of California, Berkeley

    Berkeley, United States

    27 h-index

    86 publications

    10.7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    27 h-index

    64 publications

    7.8K citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    20 h-index

    69 publications

    9.6K citations

  5. Stony Brook University

    Stony Brook, United States

    15 h-index

    29 publications

    2.5K citations

  6. University of Wisconsin–Madison

    Madison, United States

    14 h-index

    53 publications

    2.5K citations

  7. Harvard University

    Cambridge, United States

    13 h-index

    53 publications

    6.2K citations

  8. Johns Hopkins University

    Baltimore, United States

    12 h-index

    30 publications

    3.3K citations

1–8 of 451

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 45 publications · 4K citations

    38

    h-index

  2. Journal of Biological Chemistry

    JBC · 51 publications · 3.4K citations

    34

    h-index

  3. Molecular and Cellular Biology

    MCB · 40 publications · 3.6K citations

    32

    h-index

  4. Genes & Development

    31 publications · 4.2K citations

    30

    h-index

  5. Nucleic Acids Research

    31 publications · 1.3K citations

    22

    h-index

1–5