Concepedia

Organizer Function

Organizer Function is a developmental biological mechanism that directs the establishment of embryonic polarity and induces germ layer specification through localized signaling centers, distinguished by its capacity to initiate and spatially coordinate axis formation and cell fate determination in vertebrate embryos.

127

Publications

11.7K

Citations

549

Authors

206

Institutions

Publications per year

2017–2026

20

Parents

Publications

127

Requirement for LIml in head-organizer function

William Shawlot, Richard R. Behringer · Nature · 1995 · 809 citations

, , +2

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

Ken W.Y. Cho, Bruce Blumberg, Herbert Steinbeißer · Cell · 1991 · 802 citations · Full text

, , +10

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

Ali Hemmati‐Brivanlou, Olivia Kelly, Douglas A. Melton · Cell · 1994 · 759 citations

, , +7

The organizer factors Chordin and Noggin are required for mouse forebrain development

Daniel Bachiller, John Klingensmith, Caroline Kemp et al. · Nature · 2000 · 530 citations

, , +14

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early <i>Xenopus</i> embryo

Shun-ichiro Iemura, Takamasa Yamamoto, Chiyo Takagi et al. · Proceedings of the National Academy of Sciences · 1998 · 443 citations · Full text

, , +17

1–5 of 127

Authors

549

  1. IB
    Igor B. Dawid

    National Institutes of Health, United States

    3 publications · 243 citations

    3

    h-index

  2. RM
    Richard M. Harland

    University of California, Berkeley, United States

    3 publications · 646 citations

    3

    h-index

  3. HS
    Herbert Steinbeißer

    Heidelberg University, Germany

    3 publications · 875 citations

    3

    h-index

  4. TM
    Tracy Mitchell

    University of California, San Francisco, United States

    2 publications · 40 citations

    2

    h-index

  5. AF
    Abraham Fainsod

    Hebrew University of Jerusalem, Israel

    2 publications · 37 citations

    2

    h-index

1–5 of 549

Institutions

206

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    8 h-index

    24 publications

    5.3K citations

  2. Inserm

    Paris, France

    8 h-index

    28 publications

    1.8K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    23 publications

    2K citations

  4. University of Pennsylvania

    Philadelphia, United States

    7 h-index

    18 publications

    1.1K citations

  5. National Institutes of Health

    Bethesda, United States

    7 h-index

    18 publications

    1.4K citations

  6. University of California, Berkeley

    Berkeley, United States

    6 h-index

    13 publications

    2.5K citations

  7. Harvard University

    Cambridge, United States

    5 h-index

    9 publications

    4.1K citations

  8. Washington University in St. Louis

    St Louis, United States

    4 h-index

    7 publications

    857 citations

1–8 of 206

Venues

  1. Development

    22 publications · 2.1K citations

    19

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 1.1K citations

    7

    h-index

  3. Nature

    7 publications · 2.4K citations

    7

    h-index

  4. 6

    h-index

  5. Developmental Biology

    6 publications · 292 citations

    6

    h-index

1–5