Concepedia

Ontogeny-based Dosing

Ontogeny-Based Dosing is a pediatric drug dosing strategy that belongs to the category of pharmacokinetic and pharmacodynamic modeling approaches, distinguished by its explicit integration of age-dependent physiological and biochemical maturation processes to tailor drug doses according to the developmental stage of the individual.

5

Publications

317

Citations

35

Authors

17

Institutions

Publications per year

2017–2026

2

Parents

Publications

5

Genetic-based dosing in orthopedic patients beginning warfarin therapy

Eric A. Millican, Petra Lenzini, Paul E. Milligan et al. · Blood · 2007 · 178 citations · Full text

, , +12

Population pharmacokinetics and dose simulation of carvedilol in paediatric patients with congestive heart failure

Stefanie Albers, Bernd Meibohm, Thomas S. Mir et al. · British Journal of Clinical Pharmacology · 2007 · 65 citations · Full text

, , +17

Predicting the “First dose in children” of CYP3A‐metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7‐CYP3A4 switch at young ages

Ashley Strougo, Ashraf Yassen, Claire Monnereau et al. · The Journal of Clinical Pharmacology · 2014 · 37 citations

, , +16

Ontogeny Related Changes in the Pediatric Liver Metabolome

Christopher M. Wilson, Qian Li, Roger Gaedigk et al. · Frontiers in Pediatrics · 2020 · 21 citations · Full text

, , +17

Model Informed Pediatric Development Applied to Bilastine: Ontogenic PK Model Development, Dose Selection for First Time in Children and PK Study Design

Valvanera Vozmediano, Ander Sologuren, John C. Lukas et al. · Pharmaceutical Research · 2017 · 16 citations

, , +17

1–5 of 5

Authors

35

  1. PE
    Paul E. Milligan

    Washington University in St. Louis, United States

    1 publications · 178 citations

    1

    h-index

  2. RS
    R. Stephen J. Burnett

    Barnes-Jewish Hospital, United States

    1 publications · 178 citations

    1

    h-index

  3. DV
    Deepak Voora

    Duke University, United States

    1 publications · 178 citations

    1

    h-index

  4. LG
    Leonard Grosso

    Saint Louis University, United States

    1 publications · 178 citations

    1

    h-index

  5. GR
    Gloria R. Grice

    University of Health Sciences and Pharmacy, United States

    1 publications · 178 citations

    1

    h-index

1–5 of 35

Institutions

17

  1. University of Health Sciences and Pharmacy

    St Louis, United States

    1 h-index

    2 publications

    356 citations

  2. Children's Mercy Hospital

    Kansas City, United States

    1 h-index

    3 publications

    63 citations

  3. Leiden University

    Leiden, The Netherlands

    1 h-index

    3 publications

    111 citations

  4. Heinrich Heine University Düsseldorf

    Düsseldorf, Germany

    1 h-index

    4 publications

    260 citations

  5. Deakin University

    Burwood, Australia

    1 h-index

    1 publications

    16 citations

  6. Astellas Pharma (Netherlands)

    Leiden, Netherlands

    1 h-index

    4 publications

    148 citations

  7. Washington University in St. Louis

    St Louis, United States

    1 h-index

    13 publications

    2.3K citations

  8. Universität Hamburg

    Hamburg, Germany

    1 h-index

    4 publications

    260 citations

1–8 of 17

Venues

  1. Blood

    1 publications · 178 citations

    1

    h-index

  2. British Journal of Clinical Pharmacology

    BJCP · 1 publications · 65 citations

    1

    h-index

  3. The Journal of Clinical Pharmacology

    1 publications · 37 citations

    1

    h-index

  4. Frontiers in Pediatrics

    1 publications · 21 citations

    1

    h-index

  5. Pharmaceutical Research

    1 publications · 16 citations

    1

    h-index

1–5