Concepedia

Off-target Toxicity Evaluation

Off-Target Toxicity Evaluation is a preclinical safety assessment method that identifies and characterizes adverse biological effects of a therapeutic agent mediated by interactions with unintended molecular targets outside the primary pharmacological pathway.

52

Publications

5.1K

Citations

491

Authors

163

Institutions

Publications per year

2017–2026

32

Parents

Publications

52

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

Gregory L. Beatty, Andrew R. Haas, Marcela V. Maus et al. · Cancer Immunology Research · 2013 · 860 citations · Full text

, , +17

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

Ann Lin, Christopher J. Giuliano, Ann Palladino et al. · Science Translational Medicine · 2019 · 776 citations · Full text

, , +6

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

Marcela V. Maus, Andrew R. Haas, Gregory L. Beatty et al. · Cancer Immunology Research · 2013 · 592 citations · Full text

, , +17

Local bacteria affect the efficacy of chemotherapeutic drugs

Panos Lehouritis, Joanne Cummins, Michael Stanton et al. · Scientific Reports · 2015 · 304 citations · Full text

, , +17

The Role of Matrix Metalloproteinases in Colorectal Cancer

Anan Said, Jean‐Pierre Raufman, Guofeng Xie · Cancers · 2014 · 227 citations · Full text

, , +16

1–5 of 52

Authors

491

  1. CH
    Carl H. June

    University of Pennsylvania, United States

    3 publications · 1.5K citations

    3

    h-index

  2. EE
    Edward‐Sam Edwin

    Manonmaniam Sundaranar University, India

    2 publications · 98 citations

    2

    h-index

  3. PV
    Prabhakaran Vasantha‐Srinivasan

    Manonmaniam Sundaranar University, India

    2 publications · 98 citations

    2

    h-index

  4. MK
    Michael Kalos

    University of Pennsylvania, United States

    2 publications · 1.5K citations

    2

    h-index

  5. GL
    Gregory L. Beatty

    University of Pennsylvania, United States

    2 publications · 1.5K citations

    2

    h-index

1–5 of 491

Institutions

163

  1. Center for Cancer Research

    Bethesda, United States

    3 h-index

    18 publications

    1.4K citations

  2. Roche (Switzerland)

    Basel, Switzerland

    3 h-index

    5 publications

    613 citations

  3. University of Pennsylvania

    Philadelphia, United States

    3 h-index

    28 publications

    16.1K citations

  4. Tianjin University

    Tianjin, China

    2 h-index

    11 publications

    516 citations

  5. Stanford University

    Stanford, United States

    2 h-index

    32 publications

    4.5K citations

  6. King Saud University

    Riyadh, Saudi Arabia

    2 h-index

    4 publications

    196 citations

  7. University of Michigan

    Ann Arbor, United States

    2 h-index

    5 publications

    418 citations

  8. United States Department of Agriculture

    Washington, United States

    2 h-index

    2 publications

    98 citations

1–8 of 163

Venues

  1. Molecular Cancer Therapeutics

    MCT · 4 publications · 217 citations

    4

    h-index

  2. Clinical Cancer Research

    2 publications · 118 citations

    2

    h-index

  3. Scientific Reports

    2 publications · 326 citations

    2

    h-index

  4. Science Translational Medicine

    STM · 2 publications · 956 citations

    2

    h-index

  5. Molecular Pharmaceutics

    2 publications · 144 citations

    2

    h-index

1–5