Concepedia

Nucleic Acid Sequence Optimization

Nucleic Acid Sequence Optimization is a computational or experimental methodology that systematically refines the linear arrangement of nucleotides in a nucleic acid sequence to enhance a specific functional or structural property, distinguishing it from general sequence design by its focus on iterative improvement toward predefined biochemical, biophysical, or expression-related performance criteria.

77

Publications

4.6K

Citations

239

Authors

102

Institutions

Publications per year

2017–2026

13

Parents

Publications

77

OPTIMIZER: a web server for optimizing the codon usage of DNA sequences

Pere Puigbò, Efrain Guzman, A. Romeu et al. · Nucleic Acids Research · 2007 · 620 citations · Full text

, , +13

An algorithm for selection of functional siRNA sequences

Mohammed Amarzguioui, Hans Prydz · Biochemical and Biophysical Research Communications · 2004 · 438 citations

, , +12

Selection of optimal DNA oligos for gene expression arrays

Fugen Li, Gary D. Stormo · Bioinformatics · 2001 · 227 citations · Full text

, , +11

Paradigms for computational nucleic acid design

Robert M. Dirks · Nucleic Acids Research · 2004 · 215 citations · Full text

, , +16

The GeneOptimizer Algorithm: using a sliding window approach to cope with the vast sequence space in multiparameter DNA sequence optimization

David Raab, Marcus Graf, Frank Notka et al. · Systems and Synthetic Biology · 2010 · 212 citations · Full text

, , +13

1–5 of 77

Authors

239

  1. ZI
    Zuwairie Ibrahim

    University of Technology Malaysia, Malaysia

    6 publications · 88 citations

    6

    h-index

  2. JX
    Jin Xu

    Huazhong University of Science and Technology, China

    4 publications · 107 citations

    4

    h-index

  3. BW
    Bin Wang

    Dalian University of Technology, China

    4 publications · 100 citations

    4

    h-index

  4. NK
    Noor Khalid

    University of Technology Malaysia, Malaysia

    4 publications · 62 citations

    4

    h-index

  5. MK
    Marzuki Khalid

    University of Technology Malaysia, Malaysia

    3 publications · 52 citations

    3

    h-index

1–5 of 239

Institutions

102

  1. University of Technology Malaysia

    Johor Bahru, Malaysia

    6 h-index

    26 publications

    406 citations

  2. Dalian University

    Dalian, China

    4 h-index

    12 publications

    329 citations

  3. Huazhong University of Science and Technology

    Wuhan, China

    3 h-index

    12 publications

    240 citations

  4. California Institute of Technology

    Pasadena, United States

    3 h-index

    6 publications

    933 citations

  5. Peking University

    Beijing, China

    3 h-index

    3 publications

    81 citations

  6. University of Washington

    Seattle, United States

    2 h-index

    2 publications

    37 citations

  7. Indiana University Bloomington

    Bloomington, United States

    2 h-index

    8 publications

    701 citations

  8. University of Malaya

    Kuala Lumpur, Malaysia

    2 h-index

    3 publications

    33 citations

1–8 of 102

Venues

  1. Nucleic Acids Research

    11 publications · 1.4K citations

    10

    h-index

  2. Bioinformatics

    5 publications · 419 citations

    5

    h-index

  3. BMC Bioinformatics

    2 publications · 83 citations

    2

    h-index

  4. Journal of Computational Chemistry

    2 publications · 216 citations

    2

    h-index

  5. IEEE Transactions on NanoBioscience

    2 publications · 66 citations

    2

    h-index

1–5