Concepedia

Nucleation-polymerization Model

The Nucleation-Polymerization Model is a theoretical framework in protein misfolding dynamics that explains the formation of prion aggregates through an initial rate-limiting nucleation event followed by rapid polymerization of misfolded monomers into amyloid fibrils.

67

Publications

5.7K

Citations

221

Authors

122

Institutions

Publications per year

2017–2026

9

Parents

Publications

67

Mechanism of Prion Propagation: Amyloid Growth Occurs by Monomer Addition

Sean R. Collins, Adam D. Douglass, Ronald D. Vale et al. · PLoS Biology · 2004 · 515 citations · Full text

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Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

Wei‐Feng Xue, Steve W. Homans, Sheena E. Radford · Proceedings of the National Academy of Sciences · 2008 · 486 citations · Full text

, , +17

Nucleation–elongation: a mechanism for cooperative supramolecular polymerization

Dahui Zhao, Jeffrey S. Moore · Organic & Biomolecular Chemistry · 2003 · 475 citations

, , +16

A kinetic model for amyloid formation in the prion diseases: importance of seeding.

Jon H. Come, P. E. Fraser, Peter T. Lansbury · Proceedings of the National Academy of Sciences · 1993 · 395 citations

, , +17

Laminin polymerization in vitro. Evidence for a two-step assembly with domain specificity.

Peter D. Yurchenco, Effie C. Tsilibary, Aristidis Charonis et al. · Journal of Biological Chemistry · 1985 · 265 citations · Full text

, , +17

1–5 of 67

Authors

221

  1. MR
    M. Romero

    Pontificia Universidad Católica de Chile, Chile

    2 publications · 43 citations

    2

    h-index

  2. DL
    David L. Powers

    Clarkson University, United States

    2 publications · 411 citations

    2

    h-index

  3. MJ
    Mohammed J. Zaki

    Rensselaer Polytechnic Institute, United States

    2 publications · 49 citations

    2

    h-index

  4. EJ
    Elmar Jobs

    Forschungszentrum Jülich, Germany

    2 publications · 185 citations

    2

    h-index

  5. ET
    Evan T. Powers

    Scripps Research Institute, United States

    2 publications · 411 citations

    2

    h-index

1–5 of 221

Institutions

122

  1. University of California, San Francisco

    San Francisco, United States

    4 h-index

    10 publications

    2.3K citations

  2. Scripps Research Institute

    San Diego, United States

    3 h-index

    4 publications

    621 citations

  3. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    9 publications

    376 citations

  4. City College of New York

    New York, United States

    2 h-index

    6 publications

    82 citations

  5. University of California, Berkeley

    Berkeley, United States

    2 h-index

    5 publications

    292 citations

  6. Clarkson University

    Potsdam, United States

    2 h-index

    2 publications

    411 citations

  7. Sorbonne Université

    Paris, France

    2 h-index

    2 publications

    56 citations

  8. National Taiwan University of Science and Technology

    Taipei, Taiwan

    2 h-index

    8 publications

    157 citations

1–8 of 122

Venues

  1. Journal of Biological Chemistry

    JBC · 6 publications · 596 citations

    6

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 1.3K citations

    4

    h-index

  3. Biophysical Journal

    4 publications · 609 citations

    4

    h-index

  4. Biochemistry

    4 publications · 344 citations

    4

    h-index

  5. 2

    h-index

1–5