Concepedia

Nonsynonymous Substitution

A Nonsynonymous Substitution is a type of nucleotide substitution in a protein-coding sequence that results in a change in the amino acid sequence due to an altered codon, thereby distinguishing it from synonymous substitutions that do not affect the encoded amino acid.

525

Publications

56.7K

Citations

2.2K

Authors

754

Institutions

Publications per year

2017–2026

54

Variants

Replacement Substitution

Parents

Publications

525

Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

M Nei, T Gojobori · Molecular Biology and Evolution · 1986 · 5K citations · Full text

, , +13

Statistical methods for detecting molecular adaptation

Ziheng Yang, Joseph P. Bielawski · Trends in Ecology & Evolution · 2000 · 1.9K citations · Full text

, , +15

Estimating Synonymous and Nonsynonymous Substitution Rates Under Realistic Evolutionary Models

Ziheng Yang, Rasmus Nielsen · Molecular Biology and Evolution · 2000 · 1.8K citations

, , +13

Likelihood Models for Detecting Positively Selected Amino Acid Sites and Applications to the HIV-1 Envelope Gene

Rasmus Nielsen, Ziheng Yang · Genetics · 1998 · 1.7K citations · Full text

, , +12

Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution

Zefeng Yang · Molecular Biology and Evolution · 1998 · 1.5K citations · Full text

, , +15

1–5 of 525

Authors

2.2K

  1. ZY
    Ziheng Yang

    University College London, United Kingdom

    9 publications · 6.3K citations

    9

    h-index

  2. TG
    Takashi Gojobori

    National Institute of Genetics, Japan

    7 publications · 1K citations

    7

    h-index

  3. JP
    Joseph P. Bielawski

    Dalhousie University, Canada

    6 publications · 2.2K citations

    6

    h-index

  4. YS
    Yoko Satta

    The Graduate University for Advanced Studies, SOKENDAI, Japan

    6 publications · 360 citations

    6

    h-index

  5. WL
    Wen‐Hsiung Li

    University of Chicago, United States

    6 publications · 2.3K citations

    6

    h-index

1–5 of 2.2K

Institutions

754

  1. Pennsylvania State University

    State College, United States

    19 h-index

    36 publications

    6.2K citations

  2. National Institute of Genetics

    Mishima, Japan

    19 h-index

    30 publications

    6.4K citations

  3. University College London

    London, United Kingdom

    16 h-index

    41 publications

    12.5K citations

  4. Chinese Academy of Sciences

    Beijing, China

    14 h-index

    70 publications

    6K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    48 publications

    2.6K citations

  6. The University of Tokyo

    Tokyo, Japan

    12 h-index

    24 publications

    1.2K citations

  7. University of Chicago

    Chicago, United States

    11 h-index

    20 publications

    5.6K citations

  8. Cornell University

    Ithaca, United States

    10 h-index

    39 publications

    14.9K citations

1–8 of 754

Venues

  1. Molecular Biology and Evolution

    MBE · 136 publications · 21.4K citations

    67

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 38 publications · 10.2K citations

    35

    h-index

  3. Genetics

    37 publications · 4.6K citations

    33

    h-index

  4. Journal of Virology

    JVI · 18 publications · 1.7K citations

    18

    h-index

  5. Journal of Molecular Evolution

    12 publications · 1.5K citations

    12

    h-index

1–5