Concepedia

Nonlinear Two-compartment Models

Nonlinear Two-Compartment Models is a pharmacokinetic modeling framework in which the transfer kinetics between two interconnected compartments exhibit nonlinear dynamics, typically due to capacity-limited processes such as saturable elimination or absorption, distinguishing it from linear two-compartment models that assume first-order kinetics.

53

Publications

3.5K

Citations

268

Authors

117

Institutions

Publications per year

2017–2026

9

Parents

Publications

53

Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data. Generalizations

Clifford S. Patlak, Ronald G. Blasberg · Journal of Cerebral Blood Flow & Metabolism · 1985 · 1.7K citations · Full text

, , +17

Copepod grazing and the biogeochemical fate of diatom iron

David A. Hutchins, Wen‐Xiong Wang, Nicholas S. Fisher · Limnology and Oceanography · 1995 · 129 citations · Full text

, , +16

A two-compartment cell for using soluble benzoquinone derivatives as active materials in lithium secondary batteries

Hiroshi Senoh, Masaru Yao, Hikarí Sakaebe et al. · Electrochimica Acta · 2011 · 123 citations

, , +17

Equilibrium versus Compartmental Analysis for Assessment of the Vesicular Monoamine Transporter Using (+)-α-[ <sup>11</sup> C]Dihydrotetrabenazine (DTBZ) and Positron Emission Tomography

Robert A. Koeppe, Kirk A. Frey, Akito Kume et al. · Journal of Cerebral Blood Flow & Metabolism · 1997 · 90 citations · Full text

, , +16

A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine*

Gary F. Nieman, David Brown, Joydeep Sarkar et al. · Critical Care Medicine · 2012 · 73 citations

, , +17

1–5 of 53

Authors

268

  1. AA
    Angelo Avogaro

    University of Padua, Italy

    2 publications · 51 citations

    2

    h-index

  2. DA
    D. Austbø

    Norwegian University of Life Sciences, Norway

    2 publications · 51 citations

    2

    h-index

  3. IR
    I. Rosenfeld

    Norwegian University of Life Sciences, Norway

    2 publications · 51 citations

    2

    h-index

  4. GF
    Gary F. Nieman

    SUNY Upstate Medical University, United States

    1 publications · 73 citations

    1

    h-index

  5. TT
    Takuto Takahashi

    University of Minnesota, United States

    1 publications · 26 citations

    1

    h-index

1–5 of 268

Institutions

117

  1. Norwegian University of Life Sciences

    Ås, Norway

    2 h-index

    5 publications

    132 citations

  2. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    10 publications

    336 citations

  3. University of Padua

    Padua, Italy

    2 h-index

    5 publications

    168 citations

  4. University of Michigan

    Ann Arbor, United States

    2 h-index

    8 publications

    580 citations

  5. National Research Council

    Rome, Italy

    2 h-index

    4 publications

    144 citations

  6. Aston University

    Birmingham, United Kingdom

    1 h-index

    2 publications

    94 citations

  7. Max Planck Society

    Munich, Germany

    1 h-index

    2 publications

    44 citations

  8. Anderson Orthopaedic Research Institute

    Alexandria, United States

    1 h-index

    1 publications

    27 citations

1–8 of 117

Venues

  1. Journal of Cerebral Blood Flow & Metabolism

    4 publications · 1.9K citations

    4

    h-index

  2. PubMed

    Repository · 3 publications · 93 citations

    3

    h-index

  3. Antimicrobial Agents and Chemotherapy

    AAC · 3 publications · 82 citations

    3

    h-index

  4. Journal of Pharmaceutical Sciences

    3 publications · 77 citations

    3

    h-index

  5. Journal of Animal Science

    3 publications · 77 citations

    3

    h-index

1–5