Concepedia

Neochromosome Construction

Neochromosome Construction is a methodological framework in chromosome engineering that enables the de novo assembly of artificial chromosomes through the targeted integration and stabilization of genomic elements, distinguishing it from other chromosomal modifications by its capacity to generate autonomous, heritable genetic structures lacking native chromosomal backbones.

6

Publications

366

Citations

85

Authors

44

Institutions

Publications per year

2017–2026

4

Parents

Publications

6

The Architecture and Evolution of Cancer Neochromosomes

Dale W. Garsed, Owen J. Marshall, Vincent Corbin et al. · Cancer Cell · 2014 · 200 citations · Full text

, , +12

Design, construction, and functional characterization of a tRNA neochromosome in yeast

Daniel Schindler, Roy Walker, Shuangying Jiang et al. · Cell · 2023 · 81 citations · Full text

, , +17

A supernumerary designer chromosome for modular <i>in vivo</i> pathway assembly in <i>Saccharomyces cerevisiae</i>

Eline D. Postma, Sofia Dashko, Lars van Breemen et al. · Nucleic Acids Research · 2020 · 42 citations · Full text

, , +17

Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome

Hugh D. Goold, Heinrich Kroukamp, Paige E. Erpf et al. · Nature Communications · 2025 · 27 citations · Full text

, , +17

Building a eukaryotic chromosome arm by de novo design and synthesis

Shuangying Jiang, Zhouqing Luo, Jie Wu et al. · Nature Communications · 2023 · 18 citations · Full text

, , +17

1–5 of 6

Authors

85

  1. YC
    Yizhi Cai

    University of Edinburgh, United Kingdom

    3 publications · 109 citations

    3

    h-index

  2. JD
    Junbiao Dai

    Shenzhen Institutes of Advanced Technology, China

    3 publications · 109 citations

    3

    h-index

  3. DS
    Daniel Schindler

    Max Planck Institute for Terrestrial Microbiology, Germany

    3 publications · 109 citations

    3

    h-index

  4. JD
    Jef D. Boeke

    Johns Hopkins University, United States

    3 publications · 109 citations

    3

    h-index

  5. SJ
    Shuangying Jiang

    BGI Group (China), China

    3 publications · 109 citations

    3

    h-index

1–5 of 85

Institutions

44

  1. University of Manchester

    Manchester, United Kingdom

    3 h-index

    16 publications

    681 citations

  2. BGI Group (China)

    Shenzhen, China

    3 h-index

    6 publications

    218 citations

  3. Institute for Systems Biology

    Seattle, United States

    3 h-index

    5 publications

    208 citations

  4. Johns Hopkins University

    Baltimore, United States

    2 h-index

    2 publications

    91 citations

  5. University of Edinburgh

    Edinburgh, United Kingdom

    2 h-index

    10 publications

    455 citations

  6. University of East Anglia

    Norwich, United Kingdom

    2 h-index

    4 publications

    182 citations

  7. Max Planck Institute for Terrestrial Microbiology

    Marburg, Germany

    2 h-index

    3 publications

    172 citations

  8. Institute of Biochemistry and Biophysics, Polish Academy of Sciences

    Warsaw, Poland

    2 h-index

    2 publications

    91 citations

1–8 of 44

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 1 publications · 10 citations

    1

    h-index

  2. Nucleic Acids Research

    1 publications · 42 citations

    1

    h-index

  3. Nature Communications

    1 publications · 18 citations

    1

    h-index

  4. Cytogenetic and Genome Research

    1 publications · 15 citations

    1

    h-index

  5. Cell

    1 publications · 81 citations

    1

    h-index

1–5