Concepedia

Mutational Epistasis Mapping

Mutational Epistasis Mapping is a systematic methodological framework within fitness landscape analysis that identifies and characterizes context-dependent interactions between genetic mutations by quantifying how the phenotypic effect of a mutation varies as a function of genetic background.

7

Publications

403

Citations

46

Authors

28

Institutions

Publications per year

2017–2026

4

Parents

Publications

7

Latent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels

Li Jiang, Parul Mishra, Ryan T. Hietpas et al. · PLoS Genetics · 2013 · 109 citations · Full text

, , +13

Mapping the Fitness Landscape of Gene Expression Uncovers the Cause of Antagonism and Sign Epistasis between Adaptive Mutations

Hsin-Hung Chou, Nigel F. Delaney, Jeremy A. Draghi et al. · PLoS Genetics · 2014 · 96 citations · Full text

, , +17

Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms

Justin Taylor, Xiaoli Mi, Khrystyna North et al. · Blood · 2020 · 58 citations · Full text

, , +17

Pervasive Pairwise Intragenic Epistasis among Sequential Mutations in TEM-1 β-Lactamase

Courtney E. Gonzalez, Marc Ostermeier · Journal of Molecular Biology · 2019 · 56 citations · Full text

, , +10

Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster

Stephanie M. Rollmann, Michael M. Magwire, Theodore J. Morgan et al. · Nature Genetics · 2006 · 31 citations

, , +14

1–5 of 7

Authors

46

  1. XM
    Xiaoli Mi

    Memorial Sloan Kettering Cancer Center, United States

    1 publications · 58 citations

    1

    h-index

  2. DH
    Daniel H. Wiseman

    University of Manchester, United Kingdom

    1 publications · 58 citations

    1

    h-index

  3. PJ
    Paul J. Steiner

    University of Colorado Boulder, United States

    1 publications · 30 citations

    1

    h-index

  4. RT
    Ryan T. Hietpas

    University of Massachusetts Chan Medical School, United States

    1 publications · 109 citations

    1

    h-index

  5. KB
    Konstantin B. Zeldovich

    University of Massachusetts Chan Medical School, United States

    1 publications · 109 citations

    1

    h-index

1–5 of 46

Institutions

28

  1. University of British Columbia

    Vancouver, Canada

    2 h-index

    4 publications

    165 citations

  2. Alberta Children's Hospital

    Calgary, Canada

    1 h-index

    2 publications

    46 citations

  3. Canada's Michael Smith Genome Sciences Centre

    Vancouver, Canada

    1 h-index

    3 publications

    69 citations

  4. Faculty of Public Health

    London, United Kingdom

    1 h-index

    3 publications

    174 citations

  5. Center for Systems Biology

    Boston, United States

    1 h-index

    1 publications

    96 citations

  6. University of Manchester

    Manchester, United Kingdom

    1 h-index

    1 publications

    58 citations

  7. ETH Zurich

    Zurich, Switzerland

    1 h-index

    1 publications

    96 citations

  8. Michigan State University

    East Lansing, United States

    1 h-index

    4 publications

    120 citations

1–8 of 28

Venues

  1. PLoS Genetics

    2 publications · 205 citations

    2

    h-index

  2. Molecular Biology and Evolution

    MBE · 1 publications · 30 citations

    1

    h-index

  3. Methods in enzymology on CD-ROM/Methods in enzymology

    Book series · 1 publications · 23 citations

    1

    h-index

  4. Blood

    1 publications · 58 citations

    1

    h-index

  5. Nature Genetics

    1 publications · 31 citations

    1

    h-index

1–5