Concepedia

Munc18-mediated Secretion

Munc18-Mediated Secretion is a molecular mechanism of regulated exocytosis in which the Sec1/Munc18 (SM) family protein Munc18 orchestrates vesicle docking and fusion by stabilizing syntaxin and bridging SNARE complex assembly, thereby ensuring precise control of neurotransmitter or hormone release.

125

Publications

9.1K

Citations

591

Authors

213

Institutions

Publications per year

2017–2026

19

Parents

Publications

125

A conformational switch in syntaxin during exocytosis: role of munc18

Irina Dulubova · The EMBO Journal · 1999 · 752 citations · Full text

, , +6

Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins

Jingshi Shen, David Tareste, Fabienne Paumet et al. · Cell · 2007 · 480 citations · Full text

, , +12

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

Cong Ma, Wei Li, Yibin Xu et al. · Nature Structural & Molecular Biology · 2011 · 373 citations · Full text

, , +10

Phosphorylation of Munc-18/n-Sec1/rbSec1 by Protein Kinase C

Yasuyuki Fujita, Takuya Sasaki, Koji Fukui et al. · Journal of Biological Chemistry · 1996 · 257 citations · Full text

, , +17

Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms

Anjaparavanda P. Naren, Deborah J. Nelson, Weiwen Xie et al. · Nature · 1997 · 221 citations

, , +14

1–5 of 125

Authors

591

  1. MV
    Matthijs Verhage

    Amsterdam Neuroscience, Netherlands

    13 publications · 674 citations

    11

    h-index

  2. SS
    Shuzo Sugita

    University of Toronto, Canada

    10 publications · 503 citations

    10

    h-index

  3. HY
    Herbert Y. Gaisano

    University of Toronto, Canada

    8 publications · 374 citations

    8

    h-index

  4. DC
    Debbie C. Thurmond

    Indiana University – Purdue University Indianapolis, United States

    8 publications · 385 citations

    8

    h-index

  5. JW
    Jeff W. Barclay

    University of Liverpool, United Kingdom

    8 publications · 539 citations

    8

    h-index

1–5 of 591

Institutions

213

  1. University of Toronto

    Toronto, Canada

    15 h-index

    72 publications

    2.9K citations

  2. University Health Network

    Toronto, Canada

    13 h-index

    61 publications

    2.6K citations

  3. University of Liverpool

    Liverpool, United Kingdom

    12 h-index

    60 publications

    4.4K citations

  4. The University of Queensland

    Brisbane, Australia

    8 h-index

    55 publications

    3.1K citations

  5. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    7 h-index

    21 publications

    1.1K citations

  6. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    6 h-index

    20 publications

    1.8K citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    24 publications

    2.6K citations

  8. Indiana University School of Medicine

    Indianapolis, United States

    5 h-index

    13 publications

    791 citations

1–8 of 213

Venues

  1. Journal of Biological Chemistry

    JBC · 24 publications · 2K citations

    20

    h-index

  2. Molecular Biology of the Cell

    MBC · 13 publications · 727 citations

    13

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 7 publications · 500 citations

    7

    h-index

  4. Journal of Cell Science

    5 publications · 318 citations

    5

    h-index

  5. Nature Communications

    4 publications · 348 citations

    4

    h-index

1–5