Concepedia

Munc13-mediated Priming

Munc13-Mediated Priming is a molecular mechanism in synaptic vesicle exocytosis that specifically refers to the process by which Munc13 proteins catalyze the conformational activation of syntaxin and stabilize the SNARE complex assembly, thereby rendering synaptic vesicles fusion-competent in preparation for neurotransmitter release.

86

Publications

9.6K

Citations

438

Authors

124

Institutions

Publications per year

2017–2026

30

Parents

Publications

86

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

Frédérique Varoqueaux, Albrecht Sigler, JeongSeop Rhee et al. · Proceedings of the National Academy of Sciences · 2002 · 638 citations · Full text

, , +17

β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs

Jeong-Seop Rhee, Andrea Betz, Sonja J. Pyott et al. · Cell · 2002 · 500 citations · Full text

, , +10

An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming

Janet E. Richmond, Robby M. Weimer, Erik M. Jørgensen · Nature · 2001 · 439 citations · Full text

, , +12

Functional Interaction of the Active Zone Proteins Munc13-1 and RIM1 in Synaptic Vesicle Priming

Andrea Betz, Pratima Thakur, Harald J. Junge et al. · Neuron · 2001 · 436 citations · Full text

, , +16

Differential Control of Vesicle Priming and Short-Term Plasticity by Munc13 Isoforms

Christian Rosenmund, Albrecht Sigler, Iris Augustin et al. · Neuron · 2002 · 356 citations · Full text

, , +17

1–5 of 86

Authors

438

  1. NB
    Nils Brose

    Max Planck Institute of Experimental Medicine, Germany

    35 publications · 5.1K citations

    33

    h-index

  2. CR
    Christian Rosenmund

    Charité - Universitätsmedizin Berlin, Germany

    14 publications · 3.2K citations

    14

    h-index

  3. JR
    Josep Rizo

    The University of Texas Southwestern Medical Center, United States

    12 publications · 1.5K citations

    12

    h-index

  4. FV
    Frédérique Varoqueaux

    Max Planck Institute of Experimental Medicine, Germany

    11 publications · 2.1K citations

    11

    h-index

  5. BH
    Benjamin H. Cooper

    Max Planck Institute of Experimental Medicine, Germany

    8 publications · 552 citations

    8

    h-index

1–5 of 438

Institutions

124

  1. Max Planck Institute of Experimental Medicine

    Göttingen, Germany

    32 h-index

    128 publications

    16.2K citations

  2. The University of Texas Southwestern Medical Center

    Dallas, United States

    16 h-index

    65 publications

    8.9K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    30 publications

    4.3K citations

  4. Max Planck Institute for Biophysical Chemistry

    Göttingen, Germany

    11 h-index

    36 publications

    12.2K citations

  5. Max Planck Society

    Munich, Germany

    11 h-index

    35 publications

    5.1K citations

  6. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    10 h-index

    47 publications

    3.9K citations

  7. Saarland University

    Saarbrücken, Germany

    7 h-index

    39 publications

    2.9K citations

  8. Stanford University

    Stanford, United States

    7 h-index

    25 publications

    3.9K citations

1–8 of 124

Venues

  1. eLife

    10 publications · 691 citations

    10

    h-index

  2. Journal of Neuroscience

    10 publications · 790 citations

    10

    h-index

  3. Neuron

    8 publications · 1.9K citations

    8

    h-index

  4. Journal of Biological Chemistry

    JBC · 5 publications · 339 citations

    5

    h-index

  5. The Journal of Cell Biology

    JCB · 4 publications · 437 citations

    4

    h-index

1–5