Concepedia

Multivalent Scaffold Design

Multivalent Scaffold Design is a protein engineering framework that enables the precise spatial organization of multiple functional domains or binding motifs onto a single structural scaffold to enhance avidity, specificity, and functional cooperativity in biomolecular interactions.

29

Publications

1.3K

Citations

172

Authors

51

Institutions

Publications per year

2017–2026

8

Parents

Publications

29

Fabrication and Self-Optimization of Multivalent Receptors on Nanoparticle Scaffolds

Andrew K. Boal, Vincent M. Rotello · Journal of the American Chemical Society · 2000 · 173 citations

, , +17

Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold

Yizhou Li, Roberto De Luca, Samuele Cazzamalli et al. · Nature Chemistry · 2018 · 144 citations · Full text

, , +17

Wet and Functional Adhesives from One‐Step Aqueous Self‐Assembly of Natural Amino Acids and Polyoxometalates

Jing Xu, Xiaodong Li, Jingfang Li et al. · Angewandte Chemie International Edition · 2017 · 106 citations

, , +16

Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolution

Kareem M. Ahmad, Yi Xiao · Nucleic Acids Research · 2012 · 88 citations · Full text

, , +14

Multivalent Scaffolds for Affinity Maturation of Small Molecule Cell Surface Binders and Their Application to Prostate Tumor Targeting

Valérie Humblet, Preeti Misra, Kumar R. Bhushan et al. · Journal of Medicinal Chemistry · 2008 · 72 citations · Full text

, , +17

1–5 of 29

Authors

172

  1. JV
    John V. Frangioni

    Beth Israel Deaconess Medical Center, United States

    3 publications · 177 citations

    3

    h-index

  2. NP
    Nadine Pannier

    Beth Israel Deaconess Medical Center, United States

    3 publications · 177 citations

    3

    h-index

  3. WM
    Wolfgang Maison

    Universität Hamburg, Germany

    3 publications · 177 citations

    3

    h-index

  4. XL
    Xiaodong Li

    Jilin University, China

    2 publications · 126 citations

    2

    h-index

  5. JX
    Jing Xu

    Southern University of Science and Technology, China

    2 publications · 126 citations

    2

    h-index

1–5 of 172

Institutions

51

  1. Freie Universität Berlin

    Berlin, Germany

    3 h-index

    6 publications

    186 citations

  2. Beth Israel Deaconess Medical Center

    Boston, United States

    3 h-index

    16 publications

    1K citations

  3. Justus-Liebig-Universität Gießen

    Giessen, Germany

    2 h-index

    13 publications

    864 citations

  4. Technische Universität Berlin

    Berlin, Germany

    2 h-index

    5 publications

    141 citations

  5. Jilin University

    Changchun, China

    2 h-index

    16 publications

    1K citations

  6. State Key Laboratory of Supramolecular Structure and Materials

    Changchun, China

    2 h-index

    16 publications

    1K citations

  7. Charité - Universitätsmedizin Berlin

    Berlin, Germany

    2 h-index

    4 publications

    104 citations

  8. Leibniz-Forschungsinstitut für Molekulare Pharmakologie

    Berlin, Germany

    1 h-index

    2 publications

    30 citations

1–8 of 51

Venues

  1. The Journal of Organic Chemistry

    JOC · 2 publications · 88 citations

    2

    h-index

  2. Chemical Science

    2 publications · 53 citations

    2

    h-index

  3. Journal of Combinatorial Chemistry

    1 publications · 15 citations

    1

    h-index

  4. Angewandte Chemie International Edition

    1 publications · 106 citations

    1

    h-index

  5. Oncotarget

    1 publications · 56 citations

    1

    h-index

1–5