Concepedia

Multisystem Physiological Decline

Multisystem Physiological Decline is a theoretical construct in gerontological pathophysiology that denotes the progressive, coordinated deterioration of multiple organ systems' functional reserve and regulatory capacity, distinguishing it from isolated system aging by its cumulative, cross-system nature underlying the clinical phenotype of frailty.

20

Publications

1.9K

Citations

100

Authors

74

Institutions

Publications per year

2017–2026

8

Parents

Publications

20

Hierarchical deterioration of body systems in Werner's syndrome: Implications for normal ageing

Makoto Goto · Mechanisms of Ageing and Development · 1997 · 241 citations

, , +10

A novel statistical approach shows evidence for multi-system physiological dysregulation during aging

Alan A. Cohen, Emmanuel Milot, Jian Yong et al. · Mechanisms of Ageing and Development · 2013 · 217 citations · Full text

, , +11

Allostatic Load and Frailty in Older Adults

Tara L. Gruenewald, Teresa E. Seeman, Arun S. Karlamangla et al. · Journal of the American Geriatrics Society · 2009 · 208 citations

, , +17

Homeostatic dysregulation proceeds in parallel in multiple physiological systems

Qing Li, Shengrui Wang, Emmanuel Milot et al. · Aging Cell · 2015 · 186 citations · Full text

, , +14

Frailty and its quantitative clinical evaluation

Paige Moorhouse, K. Rockwood · The Journal of the Royal College of Physicians of Edinburgh · 2012 · 178 citations · Full text

, , +15

1–5 of 20

Authors

100

  1. LP
    Linda P. Fried

    Johns Hopkins University, United States

    4 publications · 497 citations

    4

    h-index

  2. AA
    Alan A. Cohen

    Université de Sherbrooke, Canada

    3 publications · 460 citations

    3

    h-index

  3. CL
    Christopher L. Seplaki

    University of Rochester, United States

    2 publications · 243 citations

    2

    h-index

  4. EM
    Emmanuel Milot

    Université de Sherbrooke, Canada

    2 publications · 403 citations

    2

    h-index

  5. KB
    Karen Bandeen‐Roche

    Johns Hopkins University, United States

    2 publications · 274 citations

    2

    h-index

1–5 of 100

Institutions

74

  1. Université de Sherbrooke

    Sherbrooke, Canada

    3 h-index

    12 publications

    2K citations

  2. Johns Hopkins University

    Baltimore, United States

    3 h-index

    5 publications

    385 citations

  3. Columbia University

    New York, United States

    3 h-index

    3 publications

    440 citations

  4. University of Rochester

    Rochester, United States

    2 h-index

    3 publications

    269 citations

  5. National Institute on Aging

    Baltimore, United States

    2 h-index

    2 publications

    223 citations

  6. Geriatric Research Education and Clinical Center

    Pittsburgh, United States

    2 h-index

    8 publications

    437 citations

  7. Bharathiar University

    Coimbatore, India

    1 h-index

    1 publications

    27 citations

  8. Keio University

    Tokyo, Japan

    1 h-index

    1 publications

    66 citations

1–8 of 74

Venues

  1. Mechanisms of Ageing and Development

    2 publications · 458 citations

    2

    h-index

  2. The Journals of Gerontology Series A

    2 publications · 103 citations

    2

    h-index

  3. Scientific Reports

    1 publications · 45 citations

    1

    h-index

  4. Journal of the American Geriatrics Society

    1 publications · 208 citations

    1

    h-index

  5. Nephrology Dialysis Transplantation

    NDT · 1 publications · 79 citations

    1

    h-index

1–5