Concepedia

Molecular Hinges

Molecular Hinges is a structural motif in biomolecular systems that functions as a flexible joint region enabling relative motion between rigid domains of a macromolecule, thereby facilitating conformational changes essential for the molecule’s mechanical or catalytic activity.

176

Publications

11.4K

Citations

759

Authors

325

Institutions

Publications per year

2017–2026

35

Variants

Molecular Hinge

Parents

Publications

176

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Paul Towler, Bart L. Staker, Sridhar G. Prasad et al. · Journal of Biological Chemistry · 2004 · 744 citations · Full text

, , +16

Controlled Room-Temperature Positioning of Individual Molecules: Molecular Flexure and Motion

Thomas A. Jung, R. R. Schlittler, James K. Gimzewski et al. · Science · 1996 · 464 citations

, , +16

The hinge-bending mode in lysozyme

J. Andrew McCammon, Bruce R. Gelin, Martin Karplus et al. · Nature · 1976 · 380 citations

, , +11

Normal modes for specific motions of macromolecules: application to the hinge-bending mode of lysozyme.

Barbara Brooks, Martin Karplus · Proceedings of the National Academy of Sciences · 1985 · 348 citations · Full text

, , +17

Dual architectural roles of HU: Formation of flexible hinges and rigid filaments

John van Noort, Sander Verbrugge, Nora Goosen et al. · Proceedings of the National Academy of Sciences · 2004 · 312 citations · Full text

, , +15

1–5 of 176

Authors

759

  1. RN
    Ruth Nussinov

    Tel Aviv University, Israel

    5 publications · 134 citations

    5

    h-index

  2. MS
    Mark S.P. Sansom

    University of Oxford, United Kingdom

    5 publications · 325 citations

    5

    h-index

  3. MV
    Mária Vas

    Institute of Molecular Life Sciences, Hungary

    5 publications · 100 citations

    5

    h-index

  4. NS
    Nicole S. Sampson

    Stony Brook University, United States

    3 publications · 168 citations

    3

    h-index

  5. SS
    Sethuraman Sankararaman

    Indian Institute of Technology Madras, India

    3 publications · 145 citations

    3

    h-index

1–5 of 759

Institutions

325

  1. Centre National de la Recherche Scientifique

    Paris, France

    9 h-index

    27 publications

    939 citations

  2. University of Oxford

    Oxford, United Kingdom

    7 h-index

    26 publications

    1.5K citations

  3. University of California San Diego

    San Diego, United States

    6 h-index

    14 publications

    1.2K citations

  4. Hungarian Academy of Sciences

    Budapest, Hungary

    5 h-index

    18 publications

    362 citations

  5. Tel Aviv University

    Tel Aviv, Israel

    5 h-index

    9 publications

    304 citations

  6. Institute of Molecular Life Sciences

    Budapest, Hungary

    5 h-index

    19 publications

    397 citations

  7. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    7 publications

    795 citations

  8. Chinese Academy of Sciences

    Beijing, China

    5 h-index

    21 publications

    796 citations

1–8 of 325

Venues

  1. Biochemistry

    11 publications · 839 citations

    11

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 11 publications · 1.3K citations

    11

    h-index

  3. Journal of Biological Chemistry

    JBC · 11 publications · 1.4K citations

    11

    h-index

  4. Proteins Structure Function and Bioinformatics

    9 publications · 713 citations

    9

    h-index

  5. Journal of Molecular Biology

    JMB · 6 publications · 279 citations

    6

    h-index

1–5