Concepedia

Model-based Scale-up

Model-Based Scale-Up is a systematic methodology within pharmaceutical process development that employs mechanistic or empirical models to predict and optimize critical process parameters during the scale-up of lyophilization, distinguishing itself from heuristic or trial-and-error approaches by relying on quantitative representations of underlying physical and chemical phenomena.

56

Publications

2K

Citations

239

Authors

96

Institutions

Publications per year

2017–2026

23

Parents

Publications

56

Longitudinal Evaluation of a Scale-Up Model for Teaching Mathematics With Trajectories and Technologies

Douglas H. Clements, Julie Sarama, Christopher B. Wolfe et al. · American Educational Research Journal · 2012 · 179 citations

, , +15

Pilot plants, models, and scale-up methods in chemical engineering

Wilbur S. Hall · Journal of the Franklin Institute · 1957 · 135 citations

, , +16

Physical and mathematical modelling to aid scale-up of liquid chromatography

Graham H. Cowan, I.S. Gosling, J. F. Laws et al. · Journal of Chromatography A · 1986 · 102 citations

, , +13

Toward a Scale-Up Model for Replicating New Approaches to Schooling

Howard Adelman, Linda Taylor · Journal of Educational and Psychological Consultation · 1997 · 90 citations

, , +13

HPGR model verification and scale-up

M. Daniel, S. Morrell · Minerals Engineering · 2004 · 88 citations

, , +9

1–5 of 56

Authors

239

  1. FJ
    Feroz Jameel

    AbbVie (United States), United States

    3 publications · 97 citations

    3

    h-index

  2. RP
    Ralf Pörtner

    Hamburg University of Technology, Germany

    2 publications · 66 citations

    2

    h-index

  3. JK
    Joseph Kushner

    Pfizer (United States), United States

    2 publications · 62 citations

    2

    h-index

  4. TR
    Thorsten Röder

    Technische Hochschule Mannheim, Germany

    2 publications · 35 citations

    2

    h-index

  5. SS
    Sherwin Shang

    AbbVie (United States), United States

    2 publications · 69 citations

    2

    h-index

1–5 of 239

Institutions

96

  1. Eli Lilly (United States)

    Indianapolis, United States

    4 h-index

    16 publications

    368 citations

  2. AbbVie (United States)

    North Chicago, United States

    3 h-index

    18 publications

    632 citations

  3. Hamburg University of Technology

    Hamburg, Germany

    3 h-index

    9 publications

    276 citations

  4. Pfizer (United States)

    New York, United States

    3 h-index

    4 publications

    118 citations

  5. ExxonMobil (United States)

    Irving, United States

    3 h-index

    10 publications

    312 citations

  6. Purdue University West Lafayette

    West Lafayette, United States

    2 h-index

    5 publications

    190 citations

  7. Universität Hamburg

    Hamburg, Germany

    2 h-index

    8 publications

    264 citations

  8. University at Buffalo, State University of New York

    Buffalo, United States

    2 h-index

    5 publications

    343 citations

1–8 of 96

Venues

  1. Organic Process Research & Development

    5 publications · 109 citations

    5

    h-index

  2. Powder Technology

    4 publications · 82 citations

    4

    h-index

  3. AAPS PharmSciTech

    3 publications · 57 citations

    3

    h-index

  4. Chemical Engineering Science

    3 publications · 104 citations

    3

    h-index

  5. Industrial & Engineering Chemistry Research

    4 publications · 82 citations

    3

    h-index

1–5