Concepedia

Mixed Function Oxidase Induction

Mixed Function Oxidase Induction is a biochemical response mechanism in which the expression and activity of mixed function oxidase enzymes, particularly those in the cytochrome P450 family, are upregulated as a consequence of exposure to xenobiotic compounds, thereby enhancing the metabolic capacity of an organism to detoxify or bioactivate foreign chemicals.

324

Publications

12.4K

Citations

834

Authors

237

Institutions

Publications per year

2017–2026

0

Variants

Mfo Induction

Parents

Publications

324

Evidence for the Clara cell as a site of cytochrome P450-dependent mixed-function oxidase activity in lung

Michael R. Boyd · Nature · 1977 · 357 citations

, , +9

Acetaminophen Hepatotoxicity: The First 35 Years

Barry H. Rumack · Journal of Toxicology Clinical Toxicology · 2002 · 336 citations

, , +17

Testing of known carcinogens and noncarcinogens for their ability to induce unscheduled DNA synthesis in HeLa cells.

Carl N. Martin, Anne C. McDermid, R. Colin Garner · PubMed · 1978 · 246 citations

, , +12

Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system.

A L Hunter, Myron A. Holscher, Robert A. Neal · Journal of Pharmacology and Experimental Therapeutics · 1977 · 196 citations

, , +14

N-demethylation of substituted 3-(phenyl)-1-methylureas: Isolation and characterization of a microsomal mixed function oxidase from cotton

D.S. Frear, H.R. Swanson, Fred S. Tanaka · Phytochemistry · 1969 · 183 citations

, , +4

1–5 of 324

Authors

834

  1. CI
    Costas Ioannides

    University of Surrey, United Kingdom

    9 publications · 271 citations

    9

    h-index

  2. RA
    R.F. Addison

    Bedford Institute of Oceanography, Canada

    7 publications · 222 citations

    7

    h-index

  3. MC
    María Cristina Fossi

    University of Siena, Italy

    7 publications · 230 citations

    7

    h-index

  4. JR
    John R. Bend

    National Institute of Environmental Health Sciences, United States

    6 publications · 423 citations

    6

    h-index

  5. SF
    Silvano Focardi

    University of Siena, Italy

    6 publications · 184 citations

    6

    h-index

1–5 of 834

Institutions

237

  1. Cornell University

    Ithaca, United States

    10 h-index

    31 publications

    1.4K citations

  2. National Institute of Environmental Health Sciences

    Durham, United States

    10 h-index

    23 publications

    934 citations

  3. University of Surrey

    Guildford, United Kingdom

    9 h-index

    19 publications

    455 citations

  4. Oregon State University

    Corvallis, United States

    9 h-index

    37 publications

    1.3K citations

  5. University of Siena

    Siena, Italy

    8 h-index

    37 publications

    1.1K citations

  6. Fisheries and Oceans Canada

    Ottawa, Canada

    8 h-index

    28 publications

    956 citations

  7. Bedford Institute of Oceanography

    Dartmouth, Canada

    7 h-index

    21 publications

    642 citations

  8. Research Triangle Park Foundation

    Durham, United States

    7 h-index

    19 publications

    750 citations

1–8 of 237

Venues

  1. Biochemical Pharmacology

    32 publications · 1.2K citations

    22

    h-index

  2. PubMed

    Repository · 21 publications · 1.1K citations

    16

    h-index

  3. Toxicology and Applied Pharmacology

    TAAP · 22 publications · 832 citations

    16

    h-index

  4. 14

    h-index

  5. Drug Metabolism and Disposition

    11 publications · 468 citations

    11

    h-index

1–5