Concepedia

Mismatch-induced Duplex Destabilization

Mismatch-Induced Duplex Destabilization is a biophysical phenomenon in which the presence of non-complementary base pairs within a DNA duplex reduces its thermodynamic stability by disrupting hydrogen bonding and base stacking interactions, thereby lowering the melting temperature relative to a perfectly matched duplex.

33

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1.9K

Citations

104

Authors

47

Institutions

Publications per year

2017–2026

2

Parents

Publications

33

Thermodynamics of internal C.T mismatches in DNA

Hatim T. Allawi · Nucleic Acids Research · 1998 · 242 citations

, , +13

Specificity and stringency in DNA triplex formation.

Richard W. Roberts, Donald M. Crothers · Proceedings of the National Academy of Sciences · 1991 · 156 citations

, , +14

Deoxyguanosine-deoxyadenosine pairing in the d(C-G-A-G-A-A-T-T-C-G-C-G) duplex: conformation and dynamics at and adjacent to the dG.cntdot.dA mismatch site

Dinshaw J. Patel, Sharon A. Kozlowski, Satoshi Ikuta et al. · Biochemistry · 1984 · 141 citations

, , +14

The thermal stability of oligonucleotide duplexes is sequence independent in tetraalkylammonium salt solutions: application to identifying recombinant DNA clones

Kenneth Jacobs, Richard Rudersdorf, S D Neill et al. · Nucleic Acids Research · 1988 · 119 citations · Full text

, , +13

Studies on nucleic acid interactions I. Stabilities of mini-duplexes (dG<sub>2</sub>A<sub>4</sub>XA<sub>4</sub>G<sub>2</sub>.dC<sub>2</sub>T<sub>4</sub>YT<sub>4</sub>C<sub>2</sub>) and self-complementary d(GGGAAXYTTCCC) containing deoxyinosine and other mismatched bases

Yasutoshi Kawase, Shigenori Iwai, H. Inoue et al. · Nucleic Acids Research · 1986 · 103 citations · Full text

, , +17

1–5 of 33

Authors

104

  1. DJ
    Dinshaw J. Patel

    Memorial Sloan Kettering Cancer Center, United States

    2 publications · 181 citations

    2

    h-index

  2. AN
    Andrew N. Lane

    University of Louisville, United States

    2 publications · 76 citations

    2

    h-index

  3. KI
    Keiichi Itakura

    City of Hope, United States

    2 publications · 181 citations

    2

    h-index

  4. SA
    Sharon A. Kozlowski

    Alcatel Lucent (Germany), Germany

    2 publications · 181 citations

    2

    h-index

  5. KR
    Keith R. Fox

    University of Southampton, United Kingdom

    2 publications · 67 citations

    2

    h-index

1–5 of 104

Institutions

47

  1. Yale University

    New Haven, United States

    2 h-index

    5 publications

    525 citations

  2. University of Washington

    Seattle, United States

    2 h-index

    4 publications

    380 citations

  3. University of Southampton

    Southampton, United Kingdom

    2 h-index

    5 publications

    147 citations

  4. Universidade Federal de Minas Gerais

    Belo Horizonte, Brazil

    1 h-index

    2 publications

    108 citations

  5. Stanford University

    Stanford, United States

    1 h-index

    2 publications

    180 citations

  6. University of Southern California

    Los Angeles, United States

    1 h-index

    2 publications

    40 citations

  7. QIMR Berghofer Medical Research Institute

    Brisbane, Australia

    1 h-index

    1 publications

    13 citations

  8. Toshiba (Japan)

    Tokyo, Japan

    1 h-index

    1 publications

    12 citations

1–8 of 47

Venues

  1. Nucleic Acids Research

    7 publications · 634 citations

    7

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  2. Biochemistry

    6 publications · 408 citations

    6

    h-index

  3. 2

    h-index

  4. European Journal of Biochemistry

    EJB · 1 publications · 19 citations

    1

    h-index

  5. Biopolymers

    1 publications · 15 citations

    1

    h-index

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