Concepedia

Mediator Kinase Module

The Mediator Kinase Module is a distinct subcomplex within the Mediator complex that specifically regulates transcriptional initiation and reinitiation by recruiting cyclin-dependent kinases to phosphorylate the C-terminal domain of RNA polymerase II, thereby modulating gene expression.

32

Publications

2.4K

Citations

285

Authors

103

Institutions

Publications per year

2017–2026

19

Variants

Mediator Cdk Module

Parents

Publications

32

Quantitative proteomic analysis of distinct mammalian Mediator complexes using normalized spectral abundance factors

Andrew C. Paoletti, Tari Parmely, Chieri Tomomori‐Sato et al. · Proceedings of the National Academy of Sciences · 2006 · 539 citations · Full text

, , +16

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

Henri-Marc Bourbon · Nucleic Acids Research · 2008 · 365 citations · Full text

, , +13

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

Kuang‐Lei Tsai, Shigeo Sato, Chieri Tomomori‐Sato et al. · Nature Structural & Molecular Biology · 2013 · 222 citations · Full text

, , +10

Distinct roles for Mediator Cdk8 module subunits in Drosophila development

Nicolas Loncle, Muriel Boube, Laurent Joulia et al. · The EMBO Journal · 2007 · 106 citations · Full text

, , +16

Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

Iris Steinparzer, Vitaly Sedlyarov, Jonathan D. Rubin et al. · Molecular Cell · 2019 · 106 citations · Full text

, , +14

1–5 of 32

Authors

285

  1. TB
    Thomas Boyer

    The University of Texas at San Antonio Health Science Center, United States

    5 publications · 212 citations

    5

    h-index

  2. KT
    Kuang‐Lei Tsai

    Scripps Research Institute, United States

    3 publications · 301 citations

    3

    h-index

  3. RF
    Ron Firestein

    Hudson Institute of Medical Research, Australia

    3 publications · 149 citations

    3

    h-index

  4. HJ
    Hee Jong Kim

    University of Pennsylvania, United States

    2 publications · 79 citations

    2

    h-index

  5. LA
    Lauri A. Aaltonen

    University of Helsinki, Finland

    2 publications · 84 citations

    2

    h-index

1–5 of 285

Institutions

103

  1. The University of Texas at San Antonio Health Science Center

    San Antonio, United States

    5 h-index

    14 publications

    650 citations

  2. University of Helsinki

    Helsinki, Finland

    4 h-index

    26 publications

    979 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    9 publications

    1K citations

  4. Monash University

    Melbourne, Australia

    2 h-index

    16 publications

    657 citations

  5. University of British Columbia

    Vancouver, Canada

    2 h-index

    10 publications

    330 citations

  6. Hudson Institute of Medical Research

    Clayton, Australia

    2 h-index

    22 publications

    780 citations

  7. University of Kansas Medical Center

    Kansas City, United States

    2 h-index

    4 publications

    1.5K citations

  8. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    7 publications

    295 citations

1–8 of 103

Venues

  1. Molecular Cell

    3 publications · 172 citations

    3

    h-index

  2. Nucleic Acids Research

    2 publications · 432 citations

    2

    h-index

  3. Cancer Research

    2 publications · 106 citations

    2

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 616 citations

    2

    h-index

  5. The EMBO Journal

    2 publications · 124 citations

    2

    h-index

1–5